دورية أكاديمية
Regulation of MAP kinases by the VHR dual-specific phosphatase: implications for cell growth and differentiation.
| العنوان: | Regulation of MAP kinases by the VHR dual-specific phosphatase: implications for cell growth and differentiation. |
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| المؤلفون: | Cerignoli, Fabio, Rahmouni, Souad, Ronai, Ze'ev, Mustelin, Tomas |
| المصدر: | Cell Cycle, 5 (19), 2210-5 (2006) |
| بيانات النشر: | Landes Bioscience, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Cell Cycle, Cell Cycle Proteins, Cell Differentiation, Cell Proliferation, Dual Specificity Phosphatase 3, Feedback, Biochemical/physiology, Humans, Mitogen-Activated Protein Kinases/metabolism/physiology, Protein Tyrosine Phosphatases/physiology, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire |
| الوصف: | Although it is well established that a transient activation of the mitogen-activated protein kinases Erk and Jnk is a crucial step in most growth promoting signaling pathways, it has also been demonstrated that a prolonged activation of these kinases can induce differentiation, cell cycle arrest, and cell senescence. We recently found that the expression of the 21-kDa human Vaccinia H1-related (VHR) dual-specific phosphatase fluctuates during cell cycle progression and affects Erk and Jnk activity in a cell cycle-dependent manner. Cells lacking VHR arrested at the G(1)/S and G(2)/M transitions of the cell cycle and exhibited senescence phenotypes. Cells lacking VHR upregulated p21(Cip/Waf1) and downregulated many genes for cell cycle regulators, DNA replication, transcription, and mRNA processing. In the absence of VHR, the serum-induced activation of Jnk and Erk was further elevated and was required for the G(1)/S and G(2)/M blocks, which were attenuated upon Jnk and Erk inhibition. Collectively, VHR provides a long sought layer in the regulation of Jnk and Erk during cell cycle progression thereby contributing to cell cycle arrest, differentiation or senescence. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | urn:issn:1538-4101; urn:issn:1551-4005 |
| DOI: | 10.4161/cc.5.19.3267 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/4831Test |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ecTest info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsorb.4831 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.4161/cc.5.19.3267 |
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