دورية أكاديمية
Effect of high N-acetylcysteine concentrations on antibiotic activity against a large collection of respiratory pathogens
| العنوان: | Effect of high N-acetylcysteine concentrations on antibiotic activity against a large collection of respiratory pathogens |
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| المؤلفون: | Landini, G., Di Maggio, T., Sergio, F., Docquier, Jean-Denis, Rossolini, G. M., Pallecchi, L. |
| المصدر: | Antimicrobial Agents and Chemotherapy, 60 (12), 7513-7517 (2016) |
| بيانات النشر: | American Society for Microbiology, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Acinetobacter baumannii, Article, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Klebsiella pneumoniae, Acetylcysteine, Aminoglycosides, Anti-Bacterial Agents, Ceftriaxone, Drug Combinations, Drug Interactions, Humans, Imipenem, Microbial Sensitivity Tests, Penicillins, Respiratory Tract Infections, Thienamycins, Life sciences, Microbiology, Sciences du vivant, Microbiologie |
| الوصف: | The effect of high N-acetylcysteine (NAC) concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised the activity of carbapenems (of mostly imipenem and, to lesser extents, meropenem and ertapenem) in a dose-dependent fashion. We demonstrated chemical instability of carbapenems in the presence of NAC. With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased (penicillins) antibiotic activity. Copyright © 2016 Landini et al. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | urn:issn:0066-4804; urn:issn:1098-6596 |
| DOI: | 10.1128/AAC.01334-16 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/252801Test |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ecTest info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsorb.252801 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1128/AAC.01334-16 |
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