دورية أكاديمية
Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study.
| العنوان: | Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study. |
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| المؤلفون: | Kerestes, Rebecca, Laansma, Max A, Owens-Walton, Conor, Perry, Andrew, van Heese, Eva M, Al-Bachari, Sarah, Anderson, Tim J, Assogna, Francesca, Aventurato, Ítalo K, van Balkom, Tim D, Berendse, Henk W, van den Berg, Kevin R E, Betts, Rebecca, Brioschi, Ricardo, Carr, Jonathan, Cendes, Fernando, Clark, Lyles R, Dalrymple-Alford, John C, Dirkx, Michiel F, Druzgal, Jason, Durrant, Helena, Emsley, Hedley C A, Garraux, Gaëtan, Haroon, Hamied A, Helmich, Rick C, van den Heuvel, Odile A, João, Rafael B, Johansson, Martin E, Khachatryan, Samson G, Lochner, Christine, McMillan, Corey T, Melzer, Tracy R, Mosley, Philip E, Newman, Benjamin, Opriessnig, Peter, Parkes, Laura M, Pellicano, Clelia, Piras, Fabrizio, Pitcher, Toni L, Poston, Kathleen L, Rango, Mario, Roos, Annerine, Rummel, Christian, Schmidt, Reinhold, Schwingenschuh, Petra, Silva, Lucas S, Smith, Viktorija, Squarcina, Letizia, Stein, Dan J, Tavadyan, Zaruhi, Tsai, Chih-Chien, Vecchio, Daniela, Vriend, Chris, Wang, Jiun-Jie, Wiest, Roland, Yasuda, Clarissa L, Young, Christina B, Jahanshad, Neda, Thompson, Paul M, van der Werf, Ysbrand D, Harding, Ian H |
| المساهمون: | GIGA CRC In vivo Imaging-MoVeRe - ULiège, BE |
| المصدر: | Movement Disorders, 38 (12), 2269 - 2281 (2023-12) |
| بيانات النشر: | John Wiley and Sons Inc, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | MRI, Parkinson's disease, cerebellum, disease staging, Humans, Cross-Sectional Studies, Magnetic Resonance Imaging, Cerebellum, Brain, Parkinson Disease/complications, Neurology, Neurology (clinical), Human health sciences, Sciences de la santé humaine, Neurologie |
| الوصف: | [en] BACKGROUND: Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated.OBJECTIVE: To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group.METHODS: Cerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with motor symptom severity and Montreal Cognitive Assessment scores were investigated.RESULTS: Overall, people with PD had a regionally smaller posterior lobe (dmax = -0.15). HY stage-specific analyses revealed a larger anterior lobule V bilaterally (dmax = 0.28) in people with PD in HY stage 1 compared to controls. In contrast, smaller bilateral lobule VII volume in the posterior lobe was observed in HY stages 3, 4, and 5 (dmax = -0.76), which was incrementally lower with higher disease stage. Within PD, cognitively impaired individuals had lower total cerebellar volume compared to cognitively normal individuals (d = -0.17).CONCLUSIONS: We provide evidence of a dissociation between anterior "motor" lobe and posterior "non-motor" lobe cerebellar regions in PD. Whereas less severe stages of the disease are associated with larger motor lobe regions, more severe stages of the disease are marked by smaller non-motor regions. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article peer reviewed |
| اللغة: | English |
| العلاقة: | https://movementdisorders.onlinelibrary.wiley.com/doi/pdf/10.1002/mds.29611Test; urn:issn:0885-3185; urn:issn:1531-8257 |
| DOI: | 10.1002/mds.29611 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/319472Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.319472 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1002/mds.29611 |
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