دورية أكاديمية
High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study
| العنوان: | High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study |
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| المؤلفون: | Edwards, M.H., Parsons, C., Bruyère, Olivier, Petit Dop, F., Chapurlat, R., Roemer, F.W., Guermazi, A., Zaim, S., Genant, H., Reginster, Jean-Yves, Dennison, E.M., Cooper, C., The SEKOIA Study Group |
| المصدر: | Journal of Rheumatology, 43 (3), 657-65 (2016) |
| بيانات النشر: | Journal of Rheumatology Publishing Company, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Osteoarthritis, knee, progression, Natural History, Magnetic Resonance Imaging, Radiographic, Joint Space Narrowing, Human health sciences, Rheumatology, Public health, health care sciences & services, Sciences de la santé humaine, Rhumatologie, Santé publique, services médicaux & soins de santé |
| الوصف: | Objective. Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. Weinvestigated which features on baseline magnetic resonance imaging (MRI) acted as predictors ofchange in joint space width (JSW).Methods. A total of 559 men and women over the age of 50 years with clinical knee OA[Kellgren-Lawrence (KL) grade 2-3] were recruited to the placebo arm of the SEKOIA study (98centers; 18 countries). Minimal tibiofemoral joint space and KL grade on plain radiograph of the kneewere assessed at baseline and at yearly followup up to 3 years. In a subset, serial knee MRI examinationswere performed. Individuals with a bone marrow lesion (BML) ≥ grade 2 at the tibiofemoraljoint at baseline were classified as BML-positive. Relationships between change in JSW and riskfactors were assessed using linear regression.Results. The mean age of study participants was 62.8 (SD 7.5) years and 73% were female; 38.6%had BML. Mean baseline JSW was 3.65 mm. This reduced by 0.18 (0.30) mm/year in men and 0.13(0.23) mm/year in women. Those with BML had a significantly higher rate of annualized change inJSW; this relationship remained robust after adjustment for age, sex, and baseline KL grade [β =–0.10 (95% CI –0.18, –0.02) mm/yr]. Age, sex, baseline KL grade, and other MRI findings did notinfluence the rate of change in JSW.Conclusion. The rate of change in JSW was similar in men and women. BML on knee MRI predictedthe rate of radiographic change in JSW. This relationship was independent of age, sex, and baselineKL grade. (First Release January 15 2016; J Rheumatol 2016;43:657–65; doi:10.3899/jrheum.150053) |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | urn:issn:0315-162X; urn:issn:1499-2752 |
| DOI: | 10.3899/jrheum.150053 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/198514Test |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ecTest info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsorb.198514 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.3899/jrheum.150053 |
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