دورية أكاديمية
The effect of organ preservation solutions on short-term outcomes after liver transplantation: a single-center retrospective study
| العنوان: | The effect of organ preservation solutions on short-term outcomes after liver transplantation: a single-center retrospective study |
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| المؤلفون: | Van den Eynde, Jef, Achtergaele, Jannick, Fieuws, Steffen, Jochmans, Ina, Sainz-Barriga, Mauricio, Monbaliu, Diethard, Pirenne, Jacques, Gilbo, NICHOLAS |
| المصدر: | Transplant International, 34 (2), 327 - 338 (2021) |
| بيانات النشر: | Blackwell Publishing Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Histidine–Tryptophan–Ketoglutarate, IGL-1, liver transplantation, preservation solutions, University of Wisconsin, Adenosine, Glucose, Glutathione, Graft Survival, Humans, Insulin, Liver, Liver Transplantation, Mannitol, Organ Preservation, Organ Preservation Solutions, Potassium Chloride, Raffinose, Retrospective Studies, aspartate aminotransferase, HTK solution, Institute George Lopez 1 preservation solution, preservation solution, unclassified drug, University of Wisconsin solution, adenosine, glucose, glutathione, insulin, mannitol, potassium chloride, raffinose, adult, aged, allograft, Article, cholestasis, comparative study, controlled study, female, graft dysfunction, graft recipient, graft survival, human, liver injury, major clinical study, male, priority journal, retrospective study, treatment outcome, liver, organ preservation, Human health sciences, Surgery, Sciences de la santé humaine, Chirurgie |
| الوصف: | The effect of preservation solutions on outcomes has been subject of many debates but the relative benefits of the various solutions remain unclear. We retrospectively compared short-term outcomes of 885 liver transplantations performed between 1/2000 and 12/2017 and preserved with either Histidine–Tryptophan–Ketoglutarate (HTK, n = 190), University of Wisconsin (UW, n = 557), or Institute George Lopez 1 preservation solution (IGL-1, n = 139). Inverse probability of treatment weighting (IPTW) was performed to account for baseline differences between groups and analyses were adjusted for confounders. In the IPTW analyses, peak AST within 7 days was 44% higher (95% CI 15–81%, P < 0.001) in HTK than in UW. Mean model of early allograft function (MEAF) score was 0.61 points (95% CI 0.12–1.10, P = 0.01) higher in HTK than in UW. Early allograft dysfunction (EAD) was more likely to occur with HTK compared to IGL-1 (IPTW OR = 2.87, 95% CI = 1.00–8.19, P = 0.049) and UW (IPTW OR = 1.75, 95% CI = 1.06–2.88, P = 0.023). The type of preservation solution had no impact on hospital stay, ICU stay, incidence of biliary strictures, or graft and recipient survival. HTK was the least effective on reducing graft injury and increased the probability of graft dysfunction after transplantation. UW and IGL-1 were equally effective in reducing graft injury and dysfunction. © 2020 Steunstichting ESOT. Published by John Wiley & Sons Ltd. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article peer reviewed |
| اللغة: | English |
| العلاقة: | urn:issn:0934-0874; urn:issn:1432-2277 |
| DOI: | 10.1111/tri.13799 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/311960Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.311960 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1111/tri.13799 |
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