دورية أكاديمية
Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabetes.
| العنوان: | Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabetes. |
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| المؤلفون: | Camoin, Marion, Velho, Gilberto, Saulnier, Pierre-Jean, Potier, Louis, Abouleka, Yawa, Carpentier, Charlyne, Dubois, Severine, Larroumet, Alice, Rigalleau, Vincent, Gand, Elise, Bourron, Olivier, Bordier, Lyse, Scheen, André, Hadjadj, Samy, Roussel, Ronan, Marre, Michel, Mohammedi, Kamel |
| المصدر: | Cardiovascular Diabetology, 21 (1), 71 (2022-05-09) |
| بيانات النشر: | BioMed Central, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Amputation/adverse effects/methods, Cardiovascular Diseases/diagnosis/etiology/surgery, Diabetes Mellitus, Type 1/diagnosis, Humans, Lower Extremity, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Cardiovascular disease, Lower-limb amputation, Mortality, Myocardial infarction, Stroke, Type 1 diabetes mellitus, Human health sciences, Cardiovascular & respiratory systems, Sciences de la santé humaine, Systèmes cardiovasculaire & respiratoire |
| الوصف: | BACKGROUND: Cardiovascular disease (CVD) and nontraumatic lower-limb amputation (LLA) each results in reduced life expectancy in patients with type 1 diabetes, but the differential burden between these conditions is unknown. We compared the effects of CVD and LLA on the risk of mortality in people with type 1 diabetes. METHODS: We used pooled data from the SURGENE, GENEDIAB, and GENESIS prospective cohorts. Data were divided into: 1/absence of CVD (myocardial infarction and/or stroke) nor LLA, 2/history of CVD alone without LLA, 3/LLA alone without CVD or 4/both conditions at baseline. Participants with baseline history of peripheral artery disease were excluded from groups 1 and 2. The study endpoint was any death occurring during follow-up, regardless of the causes. RESULTS: Among 1169 participants (male 55%, age 40 ± 13 years, diabetes duration 23 ± 11 years), CVD, LLA or both were present at baseline in 49 (4.2%), 62 (5.3%) and 20 (1.7%) subjects, respectively. All-cause death occurred in 304 (26%) participants during 17-year follow-up, corresponding to 18,426 person-years and an incidence rate of 16 (95%CI, 15-18) per 1000 person-years. The risk of death increased in individuals with baseline history of CVD (adjusted HR 2.00 [95% CI 1.34-3.01], p = 0.0008) or LLA (2.26 [1.56-3.28], p < 0.0001), versus no condition, with an additive effect in people with both conditions (5.32 [3.14-9.00], p < 0.0001). No incremental risk of death was observed in people with CVD versus LLA (0.87 [0.54-1.41]). Compared with no condition, CVD and LLA were similarly associated with reduced life expectancy during follow-up: 2.79 (95% CI 1.26-4.32) and 3.38 (1.87-4.88) years, respectively. Combined conditions expose to 7.04 (4.76-9.31) less years of life expectancy (all p < 0.0001). CONCLUSIONS: CVD and LLA conferred a similar burden regarding mortality in type 1 diabetes population. Our findings encourage a careful consideration of people with type 1 diabetes and LLA as usually recommended for those with CVD, in terms of management of risk factors, treatments and prevention. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | urn:issn:1475-2840 |
| DOI: | 10.1186/s12933-022-01487-8 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/293801Test |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ecTest info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsorb.293801 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1186/s12933-022-01487-8 |
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