مورد إلكتروني
The Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P): A research program striving to improve blood donor safety and optimize transfusion outcomes across the lifespan.
| العنوان: | The Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P): A research program striving to improve blood donor safety and optimize transfusion outcomes across the lifespan. |
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| المؤلفون: | Josephson, Cassandra D |
| المصدر: | Transfusion; vol 62, iss 5, 982-999; 0041-1132 |
| بيانات النشر: | eScholarship, University of California 2022-05-01 |
| تفاصيل مُضافة: | Josephson, Cassandra D Glynn, Simone Mathew, Sunitha Birch, Rebecca Bakkour, Sonia Baumann Kreuziger, Lisa Busch, Michael P Chapman, Kathleen Dinardo, Carla Hendrickson, Jeanne Hod, Eldad A Kelly, Shannon Luban, Naomi Mast, Alan Norris, Philip Custer, Brian Sabino, Ester Sachais, Bruce Spencer, Bryan R Stone, Mars Kleinman, Steve National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P) |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BackgroundThe Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P) is a new iteration of prior National Heart, Lung, and Blood Institute (NHLBI) REDS programs that focus on improving transfusion recipient outcomes across the lifespan as well as the safety and availability of the blood supply.Study design and methodsThe US program includes blood centers and hospitals (22 including 6 free-standing Children's hospitals) in four geographic regions. The Brazilian program has 5 participating hemocenters. A Center for Transfusion Laboratory Studies (CTLS) and a Data Coordinating Center (DCC) support synergistic studies and activities over the 7-year REDS-IV-P program.ResultsThe US is building a centralized, vein-to-vein (V2V) database, linking information collected from blood donors, their donations, the resulting manufactured components, and data extracts from hospital electronic medical records of transfused and non-transfused patients. Simultaneously, the Brazilian program is building a donor, donation, and component database. The databases will serve as the backbone for retrospective and prospective observational studies in transfusion epidemiology, transfusion recipient outcomes, blood component quality, and emerging blood safety issues. Special focus will be on preterm infants, patients with sickle cell disease, thalassemia or cancer, and the effect of donor biologic variability and component manufacturing on recipient outcomes. A rapid response capability to emerging safety threats has resulted in timely studies related to Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2).ConclusionsThe REDS-IV-P program endeavors to improve donor-recipient-linked research with a focus on children and special populations while also maintaining the flexibility to address emerging blood safety issues. |
| مصطلحات الفهرس: | National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric, Humans, Retrospective Studies, Longevity, Child, Infant, Newborn, Premature, Blood Donors, Blood Safety, COVID-19, SARS-CoV-2, adult transfusions, linked blood-donor-recipient studies, pediatric transfusion, transfusion safety and availability, Hematology, Rare Diseases, Pediatric, Clinical Research, Patient Safety, Good Health and Well Being, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Immunology, Cardiovascular System & Hematology, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Transfusion vol 62, iss 5, 982-999 0041-1132 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt7sf537tb qt7sf537tb https://escholarship.org/uc/item/7sf537tbTest https://escholarship.orgTest/ 1391589489 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391589489 |
| قاعدة البيانات: | OAIster |
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