مورد إلكتروني
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets.
| العنوان: | Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets. |
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| المؤلفون: | Postema, Merel C |
| المصدر: | Journal of child psychology and psychiatry, and allied disciplines; vol 62, iss 10, 1202-1219; 0021-9630 |
| بيانات النشر: | eScholarship, University of California 2021-10-01 |
| تفاصيل مُضافة: | Postema, Merel C Hoogman, Martine Ambrosino, Sara Asherson, Philip Banaschewski, Tobias Bandeira, Cibele E Baranov, Alexandr Bau, Claiton HD Baumeister, Sarah Baur-Streubel, Ramona Bellgrove, Mark A Biederman, Joseph Bralten, Janita Brandeis, Daniel Brem, Silvia Buitelaar, Jan K Busatto, Geraldo F Castellanos, Francisco X Cercignani, Mara Chaim-Avancini, Tiffany M Chantiluke, Kaylita C Christakou, Anastasia Coghill, David Conzelmann, Annette Cubillo, Ana I Cupertino, Renata B de Zeeuw, Patrick Doyle, Alysa E Durston, Sarah Earl, Eric A Epstein, Jeffery N Ethofer, Thomas Fair, Damien A Fallgatter, Andreas J Faraone, Stephen V Frodl, Thomas Gabel, Matt C Gogberashvili, Tinatin Grevet, Eugenio H Haavik, Jan Harrison, Neil A Hartman, Catharina A Heslenfeld, Dirk J Hoekstra, Pieter J Hohmann, Sarah Høvik, Marie F Jernigan, Terry L Kardatzki, Bernd Karkashadze, Georgii Kelly, Clare Kohls, Gregor Konrad, Kerstin Kuntsi, Jonna Lazaro, Luisa Lera-Miguel, Sara Lesch, Klaus-Peter Louza, Mario R Lundervold, Astri J Malpas, Charles B Mattos, Paulo McCarthy, Hazel Namazova-Baranova, Leyla Nicolau, Rosa Nigg, Joel T Novotny, Stephanie E Oberwelland Weiss, Eileen O'Gorman Tuura, Ruth L Oosterlaan, Jaap Oranje, Bob Paloyelis, Yannis Pauli, Paul Picon, Felipe A Plessen, Kerstin J Ramos-Quiroga, J Antoni Reif, Andreas Reneman, Liesbeth Rosa, Pedro GP Rubia, Katya Schrantee, Anouk Schweren, Lizanne JS Seitz, Jochen Shaw, Philip Silk, Tim J Skokauskas, Norbert Soliva Vila, Juan C Stevens, Michael C Sudre, Gustavo Tamm, Leanne Tovar-Moll, Fernanda van Erp, Theo GM Vance, Alasdair Vilarroya, Oscar Vives-Gilabert, Yolanda von Polier, Georg G Walitza, Susanne Yoncheva, Yuliya N Zanetti, Marcus V Ziegler, Georg C Glahn, David C Jahanshad, Neda |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | ObjectiveSome studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.MethodsWe analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.ResultsThere was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing.ConclusionPrior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait. |
| مصطلحات الفهرس: | ENIGMA ADHD Working Group, Brain, Caudate Nucleus, Humans, Magnetic Resonance Imaging, Attention Deficit Disorder with Hyperactivity, Adolescent, Adult, Child, Autism Spectrum Disorder, Attention-deficit, brain asymmetry, brain laterality, hyperactivity disorder, large-scale data, structural MRI, Pediatric, Attention Deficit Hyperactivity Disorder (ADHD), Neurosciences, Pediatric Research Initiative, Mental Health, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Mental health, Attention‐, deficit, large‐, scale data, Clinical Sciences, Psychology, Cognitive Sciences, Developmental & Child Psychology, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Journal of child psychology and psychiatry, and allied disciplines vol 62, iss 10, 1202-1219 0021-9630 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt74x177qk qt74x177qk https://escholarship.org/uc/item/74x177qkTest https://escholarship.orgTest/ 1391594109 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391594109 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |