مورد إلكتروني
Allogeneic stem cell transplant in patients with chronic lymphocytic leukemia with 17p deletion: consult-transplant versus consult- no-transplant analysis.
| العنوان: | Allogeneic stem cell transplant in patients with chronic lymphocytic leukemia with 17p deletion: consult-transplant versus consult- no-transplant analysis. |
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| المؤلفون: | Poon, Michelle L |
| المصدر: | Leukemia & lymphoma; vol 56, iss 3, 711-715; 1042-8194 |
| بيانات النشر: | eScholarship, University of California 2015-03-01 |
| تفاصيل مُضافة: | Poon, Michelle L Fox, Patricia S Samuels, Barry I O'Brien, Susan Jabbour, Elias Hsu, Yvonne Gulbis, Alison Korbling, Martin Champlin, Richard Abruzzo, Lynne V Bassett, Roland L Khouri, Issa F |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Allogeneic stem cell transplant (alloSCT) can overcome the adverse prognosis of chronic lymphocytic leukemia with 17p deletion (17p- CLL). However, its applicability remains unclear. Since 2007, our leukemia service has referred patients with 17p- CLL for alloSCT at presentation. In this study, the outcomes of these patients were reviewed retrospectively to determine whether they underwent alloSCT and why patients did not undergo alloSCT. Fifty-two patients with 17p- CLL who were referred to the transplant service from 2007 to 2010 were identified. Of these patients, 32 (62%) did not undergo alloSCT, mainly because of treatment- or disease-related complications (n = 15). The 2-year post-referral overall survival rates of the alloSCT and non-SCT groups were 64% and 25%, respectively (p = 0.001). These findings suggest that while alloSCT is an effective therapy in patients with 17p- CLL, pre-SCT complications may preclude a significant proportion of patients from undergoing the procedure. |
| مصطلحات الفهرس: | Chromosomes, Human, Pair 17, Humans, Graft vs Host Disease, Chromosome Deletion, Treatment Outcome, Stem Cell Transplantation, Transplantation, Homologous, Survival Rate, Survival Analysis, Retrospective Studies, Follow-Up Studies, Time Factors, Adult, Aged, Middle Aged, Referral and Consultation, Female, Male, Leukemia, Lymphocytic, Chronic, B-Cell, 17p−, CLL, allogeneic transplant, Stem Cell Research, Hematology, Lymphoma, Rare Diseases, Cancer, Clinical Research, Stem Cell Research - Nonembryonic - Human, Clinical Sciences, Immunology, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Leukemia & lymphoma vol 56, iss 3, 711-715 1042-8194 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt201785mn qt201785mn https://escholarship.org/uc/item/201785mnTest https://escholarship.orgTest/ 1391595991 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391595991 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |