مورد إلكتروني
The impact of donor type on the outcome of pediatric patients with very high risk acute lymphoblastic leukemia. A study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG
| العنوان: | The impact of donor type on the outcome of pediatric patients with very high risk acute lymphoblastic leukemia. A study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG |
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| بيانات النشر: | Springer Nature 2021 |
| تفاصيل مُضافة: | Dalle, J Balduzzi, A Bader, P Pieczonka, A Yaniv, I Lankester, A Bierings, M Yesilipek, A Sedlacek, P Ifversen, M Svec, P Toporski, J Gungor, T Wachowiak, J Glogova, E Poetschger, U Peters, C Dalle J. -H. Balduzzi A. Bader P. Pieczonka A. Yaniv I. Lankester A. Bierings M. Yesilipek A. Sedlacek P. Ifversen M. Svec P. Toporski J. Gungor T. Wachowiak J. Glogova E. Poetschger U. Peters C. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Allogeneic HSCT represents the only potentially curative treatment for very high risk (VHR) ALL. Two consecutive international prospective studies, ALL-SCT-(I)BFM 2003 and 2007 were conducted in 1150 pediatric patients. 569 presented with VHR disease leading to any kind of HSCT. All patients >2 year old were transplanted after TBI-based MAC. The median follow-up was 5 years. 463 patients were transplanted from matched donor (MD) and 106 from mismatched donor (MMD). 214 were in CR1. Stem cell source was unmanipulated BM for 330 patients, unmanipulated PBSC for 135, ex vivo T-cell depleted PBSC for 62 and cord-blood for 26. There were more advanced disease, more ex vivo T-cell depletion, and more chemotherapy based conditioning regimen for patients transplanted from MMD as compared to those transplanted from MSD or MD. Median follow up (reversed Kaplan Meier estimator) was 4.99 years, median follow up of survivals was 4.88, range (0.01–11.72) years. The 4-year CI of extensive cGvHD was 13 ± 2% and 17 ± 4% (p = NS) for the patients transplanted from MD and MMD, respectively. 4-year EFS was statistically better for patients transplanted from MD (60 ± 2% vs. 42 ± 5%, p < 0.001) for the whole cohort. This difference does not exist if considering separately patients treated in the most recent study. There was no difference in 4-year CI of relapse. The 4-year NRM was lower for patients transplanted from MD (9 ± 1% vs. 23 ± 4%, p < 0.001). In multivariate analysis, donor-type appears as a negative risk-factor for OS, EFS, and NRM. This paper demonstrates the impact of donor type on overall results of allogeneic stem cell transplantation for very-high risk pediatric acute lymphoblastic leukemia with worse results when using MMD stem cell source. |
| مصطلحات الفهرس: | acute lymphoblastic leukemia, hematopoietic stem cell transplantation, mismatched donor, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/32753706 info:eu-repo/semantics/altIdentifier/wos/WOS:000555730000003 volume:56 issue:1 firstpage:257 lastpage:266 numberofpages:10 journal:BONE MARROW TRANSPLANTATION |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| أرقام أخرى: | ITBAO oai:boa.unimib.it:10281/282383 10.1038/s41409-020-01014-x info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85088982753 1308935264 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1308935264 |
| قاعدة البيانات: | OAIster |
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