مورد إلكتروني
Target Product Profile for Cutaneous Neurofibromas: Clinical Trials to Prevent, Arrest, or Regress Cutaneous Neurofibromas.
| العنوان: | Target Product Profile for Cutaneous Neurofibromas: Clinical Trials to Prevent, Arrest, or Regress Cutaneous Neurofibromas. |
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| المؤلفون: | Ly, Ina |
| المصدر: | The Journal of investigative dermatology; vol 143, iss 8, 1388-1396; 0022-202X |
| بيانات النشر: | eScholarship, University of California 2023-08-01 |
| تفاصيل مُضافة: | Ly, Ina Romo, Carlos G Gottesman, Sally Kelly, Kristen M Kornacki, Deanna York, Zachary Lee, Sang Y Rhodes, Steven D Staedtke, Verena Steensma, Matthew R Blakeley, Jaishri O Wolkenstein, Pierre |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Cutaneous neurofibromas (cNFs) are benign tumors of the skin that affect >95% of adults with neurofibromatosis type 1. Despite their benign histology, cNFs can significantly impact QOL due to disfigurement, pain, and pruritus. There are no approved therapies for cNFs. Existing treatments are limited to surgery or laser-based treatments that have had mixed success and cannot be readily applied to a large number of tumors. We review cNF treatment options that are currently available and under investigation, discuss the regulatory considerations specific to cNFs, and propose strategies to improve cNF clinical trial design and standardize clinical trial endpoints. |
| مصطلحات الفهرس: | Humans, Neurofibroma, Neurofibromatosis 1, Skin Neoplasms, Pruritus, Quality of Life, Adult, Clinical Trials and Supportive Activities, Clinical Research, Cancer, Rare Diseases, Clinical Sciences, Oncology and Carcinogenesis, Dermatology & Venereal Diseases, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf The Journal of investigative dermatology vol 143, iss 8, 1388-1396 0022-202X |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt2j02s0ht qt2j02s0ht https://escholarship.org/uc/item/2j02s0htTest https://escholarship.orgTest/ 1391573643 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391573643 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |