مورد إلكتروني
Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: A replication study
| العنوان: | Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: A replication study |
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| المصدر: | Genes, Brain and Behavior |
| بيانات النشر: | Wiley-Blackwell 2011 |
| تفاصيل مُضافة: | Ribases, M. Ramos-Quiroga, J. A. Sanchez-Mora, C. Bosch, R. Richarte, V. Palomar, G. Gastaminza, X. Biesla, A. Muenke, Maximilian Arcos-Burgos, Mauricio Castellanos, Francisco Xavier |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable developmental disorder characterized by a persistent impairing pattern of inattention and/or hyperactivity-impulsivity. Using families from a genetic isolate, the Paisa population from Colombia, and five independent datasets from four different populations (United States, Germany, Norway and Spain), a highly consistent association was recently reported between ADHD and the latrophilin 3 (LPHN3) gene, a brain-specific member of the LPHN subfamily of G-protein-coupled receptors that is expressed in ADHD-related regions, such as amygdala, caudate nucleus, cerebellum and cerebral cortex. To replicate the association between LPHN3 and ADHD in adults, we undertook a case-control association study in 334 adult patients with ADHD and 334 controls with 43 single nucleotide polymorphisms (SNPs) covering the LPNH3 gene. Single- and multiple-marker analyses showed additional evidence of association between LPHN3 and combined type ADHD in adulthood [P = 0.0019; df = 1; odds ratio (OR) = 1.82 (1.25-2.70) and P = 5.1e-05; df = 1; OR = 2.25 (1.52-3.34), respectively]. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder, and point at this new neuronal pathway as a common susceptibility factor for ADHD throughout the lifespan. |
| مصطلحات الفهرس: | Keywords: G protein coupled receptor; latrophilin 3; unclassified drug; adult; amygdaloid nucleus; article; attention deficit disorder; brain cortex; case control study; caudate nucleus; cerebellum; Colombia; controlled study; developmental disorder; female; gene i Adult ADHD; Attention-deficit/hyperactivity disorder; Case-control association study; LPHN3, Journal article |
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| الإتاحة: | Open access content. Open access content |
| أرقام أخرى: | AUANP oai:openresearch-repository.anu.edu.au:1885/78498 1601-1848 1291807198 |
| المصدر المساهم: | AUSTRALIAN NAT UNIV - PRINT REPOSITORY From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1291807198 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |