رسالة جامعية
The Studies of Epidemiology and Prognostic Markers in Epithelial Ovarian Carcinoma
| العنوان: | The Studies of Epidemiology and Prognostic Markers in Epithelial Ovarian Carcinoma |
|---|---|
| العنوان البديل: | 上皮性卵巢癌的流行病學與預後指標之研究 |
| المؤلفون: | Ying-Cheng CHIANG, 江盈澄 |
| مرشدي الرسالة: | Chi-An CHEN, Wen-Fang CHENG, 陳祈安, 鄭文芳 |
| سنة النشر: | 2016 |
| المجموعة: | National Digital Library of Theses and Dissertations in Taiwan |
| الوصف: | 104 Epithelial ovarian carcinoma has the highest mortality rate among gynecologic malignancies and is an important disease in the field. Early diagnosis is difficult due to the lack of obvious initial symptoms, therefore ovarian cancer patients are usually diagnosed at advanced stage. Current treatments include debulking surgery and adjuvant chemotherapy with the regimen of platinum and paclitaxel which have a response rate of 80% for all patients and 40-60% for advanced-staged patients, but they usually relapse after initial response and ultimately die of recurrence. Chemo-resistance is an obstacle in the managements of epithelial ovarian cancer. A clinical prognostic factor reflecting the possible mechanisms and biological characteristics of oncogenesis or chemo-resistance may be helpful in the development of new therapeutic strategies. In the first study, we conducted the nationwide database analysis through Taiwan cancer registry system from 1979 to 2008 to evaluate the pattern, incidence and prognosis of epithelial ovarian carcinomas in the last three decades. The age-specific incidence rates increased especially in serous, endometrioid and clear cell carcinoma, and the age of diagnosis decreased from sixty to fifty years old in the three decades. Patients with mucinous, endometrioid, or clear cell carcinoma had better long-term survival than patients with serous carcinoma (log rank test, p |
| Original Identifier: | 104NTU05521004 |
| نوع الوثيقة: | 學位論文 ; thesis |
| وصف الملف: | 160 |
| الإتاحة: | http://ndltd.ncl.edu.tw/handle/57284293368346860936Test |
| رقم الانضمام: | edsndl.TW.104NTU05521004 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |