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1رسالة جامعية
المؤلفون: Hirotsu, Akiko
مرشدي الرسالة: 渡邉, 大, 万代, 昌紀, 影山, 龍一郎, 廣津, 聡子, ヒロツ, アキコ
مصطلحات موضوعية: Volatile anesthetic, Sevoflurane, Interleukin-6, Neuroinflammation, Neural precursor cell, 490
الوصف: 0048
甲第22310号
医博第4551号
新制||医||1040(附属図書館)
学位規則第4条第1項該当
Doctor of Medical Science
Kyoto University
DFAMوصف الملف: application/pdf
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2رسالة جامعية
المؤلفون: Schröder, Alexandra
مرشدي الرسالة: Oppermann, Martin Prof. Dr.
مصطلحات موضوعية: 610, Sedierung, Intensivpatient, volatile Anästhetika, MIRUS, sedation, volatile anesthetic, ICU, intensive care unit, Anästhesiologie / Intensivmedizin / Notfallmedizin / Analgesie - Allgemein- und Gesamtdarstellungen (PPN619875917)
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3رسالة جامعية
المؤلفون: Carroll, Bryan Thomas
مصطلحات موضوعية: C. elegans, Caenorhabditis elegans, volatile anesthetic, unc-1, unc-24, ssu-1, ssu-2, stomatin, sulfotransferase, ASJ, RMD, DVA, fls485, sterol
الوصف: Our laboratory is primarily interested in the mechanism of action of volatile anesthetics. We have chosen to use the model system Caenorhabditis elegans to study the genetic determinants of volatile anesthetic sensitivity. Previous work has shown that the function of stomatin-like proteins is one determinant controlling volatile anesthetic response. We isolated two genetic suppressors of the volatile anesthetic-sensitive phenotype resulting from thedeficiency of neuronal stomatin-like protein. This work describes the identification and characterization of these two genetic suppressors, ssu-1 and ssu-2. ssu-1 is the only representation in the C. elegans genome of a type of enzyme involved in sending signals between cells through the circulation. While there are several types of sulfotransferase in C. elegans, ssu-1 is the only cytosolic alcohol sulfotransferase. The cytosolic alcohol sulfotransferase affects the action of signaling molecules by attaching a sulfonate to an alcohol group. Our characterization of this sulfotransferase and its relationship to stomatin-like proteins suggests a common role to the conserved structure of stomatin-like proteins. The second genetic suppressor, ssu-2, is a novel gene that is expressed in seven neurons. The location and neuronal connections of these neurons suggest that they are directly involved in coordinating locomotion, a second phenotype that is altered by stomatin deficiency. Since ssu-2 affects both locomotion and sensitivity to volatile anesthetics, this expression pattern suggests that the same neurons are involved in coordinating locomotion and modifying sensitivity to volatile anesthetics. The functional characterization of ssu-1 and the localization of the expression of ssu-2 offer complementary perspectives into the function of neuronal stomatin-like proteins.
