دورية أكاديمية
Antiviral activity of maca (Lepidium meyenii) against human influenza virus
| العنوان: | Antiviral activity of maca (Lepidium meyenii) against human influenza virus |
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| المؤلفون: | Del Valle Mendoza, Juana, Pumarola, Tomàs, Alzamora Gonzales, Libertad, Del Valle, Luis J. |
| مرشدي الرسالة: | jdevall@upc.edu.pe |
| المصدر: | Universidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPC. |
| بيانات النشر: | Elsevier B.V., 2014. |
| سنة النشر: | 2014 |
| المجموعة: | Universidad Peruana de Ciencias Aplicadas (UPC) |
| Original Material: | Del Valle Mendoza J, Pumarola T, Gonzales LA, del Valle LJ. Antiviral activity of maca (Lepidium meyenii) against human influenza virus. Asian Pacific Journal of Tropical Medicine. septiembre de 2014;7, Supplement 1:S415-20. Asian Pacific Journal of Tropical Medicine |
| مصطلحات موضوعية: | Influenza virus flu, Antiviral activity, Lepidium meyenii, Maca |
| الوصف: | Objective: To investigate antiviral activity of maca to reduce viral load in kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and MFalud-inB-, Dreasrpbeyc ctiavneilny)e. Methods: Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the eaxgtariancstts Fwluer-eA e avnaldu aFtleud- oBn v MirDusCeKs cwealsls a usssianyge dm uetshinogd aM TteTs ta sfosar yd. eAtenrtmiviinrainl ga ctthiev itiyn hoifb citoimonp oouf nthdes cytopathic effect on cell culture and multiplex RT-PCR. Results: The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. Conclusions: In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits. Financial support of this study was provided by AECID grants (PCI: C/033641/10) and AGAUR (MAT2009-11503, MAT2012-36205, 2009SGR-1208). JDVM support was provided by 1st Concurso Incentivo a la Investigación de la Universidad Peruana de Ciencias Aplicadas, Lima, Peru. Revisión por pares |
| Original Identifier: | oai:repositorioacademico.upc.edu.pe:10757/335865 |
| نوع الوثيقة: | article |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1995-7645 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S1995764514602686Test |
| DOI: | 10.1016/S1995-7645(14)60268-6 |
| الإتاحة: | http://hdl.handle.net/10757/335865Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsndl.PERUUPC.oai.repositorioacademico.upc.edu.pe.10757.335865 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
Full Text Finder | تدمد: | 19957645 |
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| DOI: | 10.1016/S1995-7645(14)60268-6 |