دورية أكاديمية
Age-Dependent Attenuation of Spatial Memory Deficits by the Histone Acetyltransferase P300/CBP-Associated Factor (PCAF) in 3XTG Alzheimer's Disease Mice
| العنوان: | Age-Dependent Attenuation of Spatial Memory Deficits by the Histone Acetyltransferase P300/CBP-Associated Factor (PCAF) in 3XTG Alzheimer's Disease Mice |
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| اللغة: | English |
| المؤلفون: | Creighton, Samantha D. (ORCID |
| المصدر: | Learning & Memory. Mar 2022 29(3):71-76. |
| الإتاحة: | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.orgTest |
| تمت مراجعته من قبل الزملاء: | Y |
| Page Count: | 6 |
| تاريخ النشر: | 2022 |
| نوع الوثيقة: | Journal Articles Reports - Research |
| الواصفات: | Alzheimers Disease, Animals, Research, Spatial Ability, Memory, Age Differences, Intervention, Biochemistry |
| DOI: | 10.1101/lm.053536.121 |
| تدمد: | 1072-0502 |
| مستخلص: | Histone acetylation, catalyzed by e, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and inhibition of the histone acetyltransferase PCAF remediated memory impairments in 3xTG-AD mice in an age-related bidirectional manner. At 3 and 6 mo of age, PCAF activation ameliorated memory deficits. At 9 mo of age, PCAF activation had no effect on spatial memory, whereas PCAF inhibition improved memory deficits in females. This work reveals a complex potential therapeutic role for PCAF in AD, initially benefitting memory but becoming detrimental as the disease progresses. |
| Abstractor: | As Provided |
| Entry Date: | 2022 |
| رقم الانضمام: | EJ1335467 |
| قاعدة البيانات: | ERIC |
Full Text Finder | تدمد: | 1072-0502 |
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| DOI: | 10.1101/lm.053536.121 |