دورية أكاديمية
Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder
| العنوان: | Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder |
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| المؤلفون: | Liang JQ, Liao HR, Xu CX, Li XL, Wei ZX, Xie GJ, Cheng Y |
| المصدر: | Neuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2689-2693 (2020) |
| بيانات النشر: | Dove Medical Press, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | major depressive disorder, exosome, mir-139-5p, biomarker, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Jia-Quan Liang,1,* Hai-Rong Liao,1,* Cai-Xia Xu,1 Xiao-Ling Li,1 Ze-Xu Wei,2 Guo-Jun Xie,1 Yong Cheng1,2 1Department of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, People’s Republic of China; 2Center on Translational Neuroscience, Minzu University of China, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guo-Jun Xie; Yong Cheng Email xiegjfs@163.com; yongcheng@muc.edu.cnBackground: MicroRNAs (miRs) have been suggested to be biomarkers to inform the diagnosis of major depressive disorder (MDD). We have previously shown that exosome-derived miR-139-5p had potential in differentiating between patients with MDD and healthy control (HC) subjects.Materials and Methods: To validate the potential of exosome-derived miR-139-5p as a biomarker for MDD, here we recruited 30 patients with MDD and 30 HC subjects, and used TaqMan probes to detect serum exosomal miR-139-5p levels.Results: The data showed that patients with MDD had significantly increased exosomal miR-139-5p levels when compared with controls. Correlation analysis suggested that sex, age, and body mass index did not significantly affect blood exosomal miR-139-5p levels in the tested subjects. The ROC curve showed that serum-derived miR-139-5p had reasonable performance in discriminating patients with MDD and HC subjects, with a sensitivity of 0.867 and specificity of 0.767, and the AUC was 0.807.Discussion: Taken together, these results demonstrated that patients with MDD were accompanied by significantly increased blood exosomal miR-139-5p levels, and exosomal miR-139-5p is a promising biomarker for the diagnosis of MDD.Keywords: major depressive disorder, exosome, miR-139-5p, biomarker |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1178-2021 |
| العلاقة: | https://www.dovepress.com/serum-exosome-derived-mir-139-5p-as-a-potential-biomarker-for-major-de-peer-reviewed-article-NDTTest; https://doaj.org/toc/1178-2021Test |
| الوصول الحر: | https://doaj.org/article/acac5491f86445da930886f7d11d20f0Test |
| رقم الانضمام: | edsdoj.5491f86445da930886f7d11d20f0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11782021 |
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