دورية أكاديمية
Does Arterialization of Portal Vein Have Any Effects in Large-for-Size Liver Transplantation? Hemodynamic, Histological, and Biomolecular Experimental Studies
| العنوان: | Does Arterialization of Portal Vein Have Any Effects in Large-for-Size Liver Transplantation? Hemodynamic, Histological, and Biomolecular Experimental Studies |
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| المؤلفون: | Rafael Rodrigues Torres, Ana Cristina Aoun Tannuri, Suellen Serafini, Alessandro Belon, Josiane Oliveira Gonçalves, Celso di Loreto, Uenis Tannuri |
| المصدر: | Journal of Investigative Surgery, Vol 35, Iss 6, Pp 1197-1207 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Surgery |
| مصطلحات موضوعية: | large-for-size liver transplantation, complications of liver transplantation, liver transplantation, pediatric liver transplantation, animal model, Surgery, RD1-811 |
| الوصف: | Background: In pediatric liver transplantation, the optimal size of the transplanted liver ranges between 0.8% and 4.0% of the recipient’s weight. Sometimes, the graft weight exceeds this upper limit, characterizing the large-for-size condition potentially associated with reduced blood flow and worsening of ischemia-reperfusion injury. Therefore, it would be beneficial to increase the portal flow through arterialization of the portal vein. Materials and methods: Fifteen pigs underwent large-for-size liver transplants. They were divided into two groups: control (CTRL 6 animals – conventional technique) and arterialization – a shunt was established between the portal vein and the splenic artery (ART 9 animals). Hemodynamic, biochemical, histological, and molecular variables were compared. Results: Arterialization resulted in a significant increase in portal vein pressure but no changes in other hemodynamic variables, as shown in the analysis of variance. It was observed lower ALT values (p = 0.007), with no differences regarding the values of blood pH and lactate (p = 0.54 and p = 0.699 respectively) or histological variables (edema, steatosis, inflammation, necrosis, and IRI – p = 1.0, p = 0.943, p = 0.174, p = 0.832, p = 0.662, respectively). The molecular studies showed significantly increased expression of IL6 after 3 hours of reperfusion (p = 0.048) and decreased expression of ICAM immediately after reperfusion (p = 0.03). The regression analysis suggested a positive influence of portal flow and pressure on biochemical parameters. Conclusion: Arterialization of the portal vein showed no histological, biochemical, or molecular benefits in large-for-size transplantation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0894-1939 1521-0553 08941939 |
| العلاقة: | https://doaj.org/toc/0894-1939Test; https://doaj.org/toc/1521-0553Test |
| DOI: | 10.1080/08941939.2021.2021333 |
| الوصول الحر: | https://doaj.org/article/94da8223ccf84faa81c020a373c6bf24Test |
| رقم الانضمام: | edsdoj.94da8223ccf84faa81c020a373c6bf24 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 08941939 15210553 |
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| DOI: | 10.1080/08941939.2021.2021333 |