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Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer

التفاصيل البيبلوغرافية
العنوان: Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer
المؤلفون: Liu‐Jing Wen, Yue‐Sheng Wang, Jie Zhang
المصدر: IET Nanobiotechnology, Vol 17, Iss 2, Pp 49-60 (2023)
بيانات النشر: Hindawi-IET, 2023.
سنة النشر: 2023
المجموعة: LCC:Biotechnology
مصطلحات موضوعية: breast cancer, doxorubicin, drug loaded hybrid micelles, elacridar, gold nanoparticles, Biotechnology, TP248.13-248.65
الوصف: Abstract The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug‐resistant in breast cancer cells. Nano‐gold micelles loaded with Dox and Elacridar (FP‐ssD@A‐E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulation rate of FP‐ssD@A‐E gradually increased, and the drug loading rate gradually decreased. FP‐ss@A‐E had a sustained‐release effect. Dox, Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E significantly improved cell apoptosis, in which, FP‐ssD@A‐E was the most significant. FP‐ssD@A‐E significantly decreased the cell viability and improved the Dox uptake. The levels of VEGFR‐1, P‐gp, IL‐6, and i‐NOS were significantly decreased after Dox, Dox + Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E treatment. It was worth noting that FP‐ssD@A‐E had the most significant effects. The prepared FP‐ssD@A‐E micelles, which were spherical in shape, uniform in particle size distribution, and had good drug loading performance and encapsulation efficiency.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1751-875X
1751-8741
العلاقة: https://doaj.org/toc/1751-8741Test; https://doaj.org/toc/1751-875XTest
DOI: 10.1049/nbt2.12102
الوصول الحر: https://doaj.org/article/37f344a0694843dfb4284ece6e85c60eTest
رقم الانضمام: edsdoj.37f344a0694843dfb4284ece6e85c60e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1751875X
17518741
DOI:10.1049/nbt2.12102