-
1دورية أكاديمية
المؤلفون: Myeongji Kim, Ayesha Jalal, Heysu Rubio-Gomez, Romina Bromberg
المصدر: BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-5 (2022)
مصطلحات موضوعية: Herpes simplex virus, Disseminated infection, Multi-organ failure, Acyclovir, Case report, Infectious and parasitic diseases, RC109-216
الوصف: Abstract Background Herpes simplex virus (HSV) rarely causes organ-invasive infection. Diagnosis and treatment for such infections are often delayed, and mortality is high. We present the first reported case of disseminated HSV-1 infection in an adult causing liver failure, myocarditis, and encephalitis in a patient who recovered after receiving parenteral acyclovir treatment. Case presentation A 46-year-old female presented with fever, chills, and malaise after 2 weeks of oral corticosteroid treatment for uveitis. She was diagnosed with disseminated HSV-1 infection with multi-organ involvement causing hepatitis, encephalitis, and myocarditis. Diagnosis was made timely using serum polymerase chain reaction (PCR) for HSV DNA and the patient was given intravenous acyclovir treatment promptly, which led to her survival without significant morbidity. Conclusions Clinicians should have a low threshold for suspecting HSV infection and ordering HSV PCR to decrease morbidity and mortality when there is a high clinical suspicion of systemic HSV infection with multi-organ involvement. Serum PCR for HSV DNA is an excellent modality for an initial diagnostic approach. Further research is warranted to elucidate causality between a course of corticosteroid therapy and systemic HSV-1 infection without major immunosuppressive comorbidities or treatments.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/1471-2334Test
-
2دورية أكاديمية
المؤلفون: Jianli Niu, Myeongji Kim, Ayesha T. Jalal, Jessica E. Goldberg, Elsa M. Acevedo Martinez, Nathalie P. Suarez Moscoso, Heysu Rubio-Gomez, Daniel Mayer, Alvaro Visbal, Candice Sareli, Paula A. Eckardt, Aharon E. Sareli
المصدر: Healthcare, Vol 11, Iss 12, p 1703 (2023)
مصطلحات موضوعية: COVID-19, Omicron variant, hospitalizations, incidental COVID-19, in-hospital mortality, intensive care services, Medicine
الوصف: The COVID-19 Omicron variant has imposed a tremendous burden on healthcare services. We characterized the types of the Omicron variant-associated hospitalizations and their associations with clinical outcomes. Consecutive adults hospitalized with COVID-19 during the Omicron variant surge period of 1–14 January 2022, were classified into one of three groups based on their clinical presentations on admission: Group 1—primary COVID-19; Group 2—extrapulmonary manifestations of COVID-19; and Group 3—incidental COVID-19. Of the 500 patients who were hospitalized, 51.4% fell into Group 1, 16.4% into Group 2, and 32.2% into Group 3. The patients in Groups 1 and 2 were older, with higher proportions of comorbidities than patients in Group 3. The Group 1 patients had the highest mortality rate (15.6%), followed by Group 2 (8.5%), and Group 3 (0.6%), with adjusted odds ratios (OR) of 22.65 (95% confidence interval [CI], 2.75–239.46; p = 0.004) and 10.95 (95% CI, 1.02–117.28; p = 0.048), respectively, compared to Group 3. Those in Group 1 showed a greater utilization of intensive care services (15.9%), followed by Group 2 (10.9%), and Group 3 (2.5%), with adjusted ORs of 7.95 (95% CI, 2.52–25.08; p < 0.001) and 5.07 (95% CI, 1.34–19.15; p = 0.017), respectively, compared to Group 3. The patients in Groups 1 and 2 had longer hospitalization stays than the patients in Group 3 (p < 0.001 and p = 0.002, respectively). Older age (≥65 years) was an independent factor associated with longer hospital stays (OR = 1.72, 95% CI, 1.07–2.77). These findings can help hospitals prioritize patient care and service planning for future SARS-CoV-2 variants.
وصف الملف: electronic resource
-
3دورية أكاديمية
المصدر: IDCases, Vol 20, Iss , Pp e00762- (2020)
مصطلحات موضوعية: SARS-COV-2, Parainfluenza virus, COVID-19, Pneumonia, Coinfection, Infectious and parasitic diseases, RC109-216
الوصف: Coronavirus 2 (SARS-CoV-2) is now considered a pandemic causing Coronavirus disease (COVID-19), multiple fatalities and morbidities which have been associated with it worldwide. We report a severe pneumonia causing acute respiratory distress syndrome due to a coinfection with SARS-COV-2 and Parainfluenza 4 virus in a Hispanic 21 year old male in Florida, USA. The case represents the importance of prompt diagnosis and awareness of the potential co-infection with other respiratory viruses and this novel deadly virus.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2214250920300706Test; https://doaj.org/toc/2214-2509Test
النص الكامل