دورية أكاديمية
Role of vitamin D on the expression of glucose transporters in L6 myotubes
| العنوان: | Role of vitamin D on the expression of glucose transporters in L6 myotubes |
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| المؤلفون: | Bubblu Tamilselvan, Krishna G Seshadri, Ganesh Venkatraman |
| المصدر: | Indian Journal of Endocrinology and Metabolism, Vol 17, Iss 7, Pp 326-328 (2013) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Diabetes, glucose transporters, vitamin D, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Altered expression of glucose transporters is a major characteristic of diabetes. Vitamin D has evolved widespread interest in the pathogenesis and prevention of diabetes. The present study was designed to investigate the effect of vitamin D in the overall regulation of muscle cell glucose transporter expression. L6 cells were exposed to type 1 and type 2 diabetic conditions and the effect of calcitriol (1,25, dihydroxy cholicalciferol) on the expression of glucose transporters was studied by real time polymerase chain reaction (RT-PCR). There was a significant decrease in glucose transporter type 1 (GLUT1), GLUT4, vitamin D receptor (VDR), and IR expression in type 1 and 2 diabetic model compared to control group. Treatment of myoblasts with 10-7 M calcitriol for 24 h showed a significant increase in GLUT1, GLUT4, VDR, and insulin receptor (IR) expression. The results indicate a potential antidiabetic function of vitamin D on GLUT1, GLUT4, VDR, and IR by improving receptor gene expression suggesting a role for vitamin D in regulation of expression of the glucose transporters in muscle cells. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2230-8210 2230-9500 |
| العلاقة: | http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=7;spage=326;epage=328;aulast=TamilselvanTest; https://doaj.org/toc/2230-8210Test; https://doaj.org/toc/2230-9500Test |
| DOI: | 10.4103/2230-8210.119642 |
| الوصول الحر: | https://doaj.org/article/094abc7d710948848898006b0f7b8310Test |
| رقم الانضمام: | edsdoj.094abc7d710948848898006b0f7b8310 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22308210 22309500 |
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| DOI: | 10.4103/2230-8210.119642 |