دورية أكاديمية
The Importance of Uncertainty Analysis and Traceable Measurements in Routine Quantitative 90Y-PET Molecular Radiotherapy: A Multicenter Experience
| العنوان: | The Importance of Uncertainty Analysis and Traceable Measurements in Routine Quantitative 90Y-PET Molecular Radiotherapy: A Multicenter Experience |
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| المؤلفون: | Marco D’Arienzo, Emilio Mezzenga, Amedeo Capotosti, Oreste Bagni, Luca Filippi, Marco Capogni, Luca Indovina, Anna Sarnelli |
| المصدر: | Pharmaceuticals, Vol 16, Iss 8, p 1142 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | 90Y, PET, dosimetry, radionuclide therapy, quantitative accuracy, uncertainty analysis, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | Molecular Radiation Therapy (MRT) is a valid therapeutic option for a wide range of malignancies, such as neuroendocrine tumors and liver cancers. In its practice, it is generally acknowledged that there is a need to evaluate the influence of different factors affecting the accuracy of dose estimates and to define the actions necessary to maintain treatment uncertainties at acceptable levels. The present study addresses the problem of uncertainty propagation in 90Y-PET quantification. We assessed the quantitative accuracy in reference conditions of three PET scanners (namely, Siemens Biograph mCT, Siemens Biograph mCT flow, and GE Discovery DST) available at three different Italian Nuclear Medicine centers. Specific aspects of uncertainty within the quantification chain have been addressed, including the uncertainty in the calibration procedure. A framework based on the Guide to the Expression of Uncertainty in Measurement (GUM) approach is proposed for modeling the uncertainty in the quantification processes, and ultimately, an estimation of the uncertainty achievable in clinical conditions is reported. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| العلاقة: | https://www.mdpi.com/1424-8247/16/8/1142Test; https://doaj.org/toc/1424-8247Test |
| DOI: | 10.3390/ph16081142 |
| الوصول الحر: | https://doaj.org/article/2da8e121064e4fdf827e6ae34d80caeeTest |
| رقم الانضمام: | edsdoj.2da8e121064e4fdf827e6ae34d80caee |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
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| DOI: | 10.3390/ph16081142 |