المؤلفون: Nacer Bellaloui, Dounya Knizia, Jiazheng Yuan, Qijian Song, Frances Betts, Teresa Register, Earl Williams, Naoufal Lakhssassi, Hamid Mazouz, Henry T. Nguyen, Khalid Meksem, Alemu Mengistu, My Abdelmajid Kassem

المصدر: International Journal of Plant Biology, Vol 15, Iss 2, Pp 452-467 (2024)

مصطلحات موضوعية: soybean, RIL, Forrest, Williams 82, linkage map, micronutrients genes, Science, Biology (General), QH301-705.5

الوصف: Soybean is a major crop in the world and an essential source for minerals, including iron (Fe) and zin (Zn). Deficiency of Fe and Zn in soil and soybean plants result in yield loss and poor seed nutritional qualities. Information on genomic regions and candidate genes controlling seed Fe and Zn accumulation in soybean seed is limited. Therefore, The objective of this research was to identify genetic regions, known as quantitative trait loci (QTL), and candidate genes that control the accumulation of Fe and Zn in soybean mature seeds. A ‘Forrest’ by ‘Williams 82’ (F × W82) recombinant inbred line (RIL) population (n = 306) was used and genotyped using a total of 5405 single nucleotides polymorphism (SNP) markers using Infinium SNP6K BeadChips. A two-year experiment was conducted across two environments: North Carolina in 2018 (NC) and Illinois in 2020 (IL). Only QTL with LOD scores ≥ 2.5, as identified by the composite interval mapping (CIM) method, are reported here. In total, 6 QTL were identified for seed Fe; specifically, 3 QTL (qFe-01-[NC-2018], qFe-02-[NC-2018], and qFe-03-[NC-2018]) were located on chromosomes 1, 2, and 6, respectively, in the NC environment, and 3 QTL (qFe-01-[IL-2020], qFe-02-[IL-2020], and qFe-03-[IL-2020]) were positioned on chromosomes 1, 2, and 12, respectively, in the IL environment. A total of 6 QTL associated with seed Zn were also identified; 4 QTL (qZn-01-[NC-2018]; qZn-02-[NC-2018]; qZn-03-[NC-2018]; and qZn-04-[NC-2018]), respectively on Chr 2, 3, 7, and 19 in NC; and 2 QTL (qZn-01-[IL-2020] and qZn-02-[IL-2020]), respectively, on Chr 5 and 8 in IL. Several functional genes encode Fe- and Zn-proteins, transcription factors, proteins-zinc finger motifs (involved in DNA binding and transcriptional regulation; crosstalk between the regulatory pathways of Zn and Fe transporters) were identified and located within the QTL interval. To our knowledge, and based on the literature available, the QTL identified here on Chr 2 and Chr 6 are novel and were not previously identified. This current research provides a new knowledge of the genetic basis of seed Fe and Zn and the markers associated with QTL. The QTL identified here will contribute to efficient marker assisted selection for higher Fe and Zn content in soybean seeds. The candidate genes and metal-responsive transcription factors may coordinate the expression of both Zn and Fe transporters in response to changes in metal availability, providing new knowledge on minerals uptake and transport mechanisms, allowing for possible genetic engineering application.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2037-0164/15/2/35Test; https://doaj.org/toc/2037-0164Test

الوصول الحر: https://doaj.org/article/50379eeec02341689e513e6834157500Test

المؤلفون: Hao Yu, Weimin Li, Xiaoxiao Liu, Qianqian Song, Junjun Li, Jin Xu

المصدر: Stress Biology, Vol 4, Iss 1, Pp 1-17 (2024)

مصطلحات موضوعية: Nickel toxicity, Micronutrients, Oxidative stress response, Phytohormones, Transcription regulatory network, Biology (General), QH301-705.5

الوصف: Abstract Nickel (Ni), a component of urease, is a micronutrient essential for plant growth and development, but excess Ni is toxic to plants. Tomato (Solanum lycopersicum L.) is one of the important vegetables worldwide. Excessive use of fertilizers and pesticides led to Ni contamination in agricultural soils, thus reducing yield and quality of tomatoes. However, the molecular regulatory mechanisms of Ni toxicity responses in tomato plants have largely not been elucidated. Here, we investigated the molecular mechanisms underlying the Ni toxicity response in tomato plants by physio-biochemical, transcriptomic and molecular regulatory network analyses. Ni toxicity repressed photosynthesis, induced the formation of brush-like lateral roots and interfered with micronutrient accumulation in tomato seedlings. Ni toxicity also induced reactive oxygen species accumulation and oxidative stress responses in plants. Furthermore, Ni toxicity reduced the phytohormone concentrations, including auxin, cytokinin and gibberellic acid, thereby retarding plant growth. Transcriptome analysis revealed that Ni toxicity altered the expression of genes involved in carbon/nitrogen metabolism pathways. Taken together, these results provide a theoretical basis for identifying key genes that could reduce excess Ni accumulation in tomato plants and are helpful for ensuring food safety and sustainable agricultural development.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2731-0450Test

الوصول الحر: https://doaj.org/article/6ae39500bc7148be803b6efb8c1685b0Test

المؤلفون: Rakesh K. Chahota, Satish K. Guleria, Pawan K. Sharma

المصدر: Journal of BioScience and Biotechnology, Vol 12, Iss 2, Pp 133-140 (2024)

مصطلحات موضوعية: biofortification, micronutrients, maize, fe, zn, ssr, β-carotene, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5

الوصف: Maize, India's third most significant crop, employs directly more than 12 million growers and accounts for 2% of the country's overall agricultural crop production value. Scientists are continuously working to counter the hidden hunger i.e. the micronutrient malnutrition. Therefore, marker assisted breeding approach has been deployed to increase the micronutrients Zn, Fe and pro-vitamin A content in the maize lines HPK-2 and CM-40 at HAREC, Kullu Himachal Pradesh, India. DNA isolation was carried out with leaf samples of 172 inbred and two parental lines (HPK-2 and CM-40). HPK-2 and CM-40 were utilized to screen 227 SSR primers of maize on PAGE/agarose gel for polymorphism. The mapping population was genotyped using 160 polymorphic SSR primers, phenotyped for Zn, Fe levels in the grain kernel through Atomic Absorption Spectrophotometer. Kernel Fe and Zn content were 35–60 ppm and 5–20 ppm, respectively. One QTL for Fe was found on chromosome I, while three QTLs for Zn were found on chromosomes I and IX. Further, IARI, New Delhi and CSKHP Agricultural University, Palampur have collaborated on two provitamin A donors for β-carotene enhancement in maize. Crossing scheme was created by combining lines with higher Zn and Fe content (BAJIM 6-01, BAJIM 6-15, BAJIM 6-08, BAJIM 6-10, BAJIM 6-06) with lines with higher β-carotene content (CIMMYT-13, CIMMYT-4). Plants containing the crtRB1 allele were selected in the foreground selection using primers HYD65F, HYD66R, and HYD62R up to BC2F4 and F6 generation. The highest β-carotene content was found in crosses between Bajim-06-10*CIMMYT-13 and BC2F4 generation, with 12.54 ppm.

وصف الملف: electronic resource

العلاقة: https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/481/344Test; https://doaj.org/toc/1314-6238Test; https://doaj.org/toc/1314-6246Test

الوصول الحر: https://doaj.org/article/5a9d6811d4da476ca8af609a54cc8eb4Test

المؤلفون: Ali A. Al-Mubarak, George Markousis Mavrogenis, Xuanxuan Guo, Marco De Bruyn, Mintu Nath, Simon P.R. Romaine, Niels Grote Beverborg, Karla Arevalo Gomez, Sietske N. Zijlstra, Dirk J. van Veldhuisen, Nilesh J. Samani, Adriaan A. Voors, Peter van der Meer, Nils Bomer

المصدر: Redox Biology, Vol 70, Iss , Pp 103046- (2024)

مصطلحات موضوعية: Selenium, Heart failure, Inflammation, Micronutrients, T cells, Medicine (General), R5-920, Biology (General), QH301-705.5

الوصف: Background: Low selenium concentrations are associated with worse outcomes in heart failure (HF). However, the underlying pathophysiologic mechanisms remain incompletely understood. Therefore, we aimed to contrast serum selenium concentrations to blood biomarker and transcriptomic profiles in patients with HF. Methods: Circulating biomarkers, whole blood transcriptomics and serum selenium measurements in a cohort of 2328 patients with HF were utilized. Penalized linear regression and gene expression analysis were used to assess biomarker and transcriptomics profiles, respectively. As a proof-of-principle, potential causal effects of selenium on excreted cytokines concentrations were investigated using human peripheral blood mononuclear cells (PBMCs). Results: Mean selenium levels were 60.6 μg/L in Q1 and 122.0 μg/L in Q4. From 356 biomarkers and 20 clinical features, the penalized linear regression model yielded 44 variables with

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2213231724000223Test; https://doaj.org/toc/2213-2317Test

الوصول الحر: https://doaj.org/article/0c28f97bfc2e48b8b3a335635dabf246Test

المؤلفون: Melina Konstantinidi, Stavroula Stoupi, Ioannis Anastasiou, Vlachos Zounelis Nikolaos, George Tsakotos, Antonios E. Koutelidakis

المصدر: Applied Sciences, Vol 14, Iss 13, p 5610 (2024)

مصطلحات موضوعية: micronutrients, functional foods, olive paste, bone mineral density, bone health indicators, postmenopausal women, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999

الوصف: Low dietary intake of calcium, vitamin D, vitamin C and magnesium has been associated with increased risk of osteoporosis. The purpose of the study was to evaluate changes in several bone health indicators and metabolic biomarkers in postmenopausal women with high osteopenia or osteoporosis, followed by a nutritional intervention program. In total, 115 apparently healthy postmenopausal women (52 ± 8 years old) were randomized into four groups: group I (n = 40) received daily 1000 mg vitamin C, 100 mcg vitamin D3, 500 mg calcium(Ca) and 300 mg magnesium (Mg); group II (n = 42) received daily 100 mcg vitamin D3, 500 mg Ca and 300 mg Mg; group III (n = 18) received daily 5 mg bisphosphonates, 100 mcg vitamin D3, 500 mg Ca and 300 mg Mg; and group IV (n = 15) received daily about 364 mg polyphenols via an innovative functional food (50 g olive paste enriched with mountain tea extract) along with 100 mcg vitamin D3, 500 mg Ca and 300 mg Mg. Groups I–III received supplementation for a year whereas group IV received supplementation for 5 months. Changes in bone health indicators and metabolic biomarkers were assessed at the beginning and at the end of the study. Anthropometric indices and whole-body bone mineral density (BMD) were also evaluated at the beginning and at the end of the intervention period. The results revealed improved elevated levels of 25(OH)D3 in groups II, III and IV (+3.71% and +1.45% and +5.62%, respectively). Significant positive changes were recorded for whole-body BMD in all four study groups. Significant beneficial changes for total cholesterol were observed in group IV (−2.07%, p < 0.05) and positive changes in group I for HDL biomarkers (+61.62%, p < 0.05). Additional larger-scale clinical trials and intervention studies are considered essential to fully investigate and elucidate associations between dietary components and biochemical indices of bone health.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-3417/14/13/5610Test; https://doaj.org/toc/2076-3417Test

الوصول الحر: https://doaj.org/article/4fee0b6cf1604500afcc8787ffbcbc0eTest

المؤلفون: Agnieszka Rudzka, Kamila Kapusniak, Dorota Zielińska, Danuta Kołożyn-Krajewska, Janusz Kapusniak, Renata Barczyńska-Felusiak

المصدر: Applied Sciences, Vol 14, Iss 11, p 4489 (2024)

مصطلحات موضوعية: micronutrients, nutritional deficiencies, supplementation, probiotics, prebiotics, synbiotics, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999

الوصف: Micronutrient deficiencies co-occur with obesity throughout the world. While many factors may contribute to this, microbiota dysbiosis is certainly one that has received a lot of attention in recent years. This work aimed to review the current state of knowledge on the role of micronutrients in obesity and the effects of interventions in microbiota on the micronutrient status of humans. Gathered evidence suggested that the supplementation of most of the deficient micronutrients for people with excess weight may have a considerable, positive impact on lipid and glucose homeostasis and a small effect on weight loss. Interestingly, the doses of micronutrient supplementation that allowed for achieving the best results for most of the minerals and vitamins exceeded the tolerable upper intake levels. To avoid negative effects associated with an overdose of vitamins and minerals, applying microbiota interventions could be considered. Pro- and prebiotics were shown to improve the micronutrient status of humans, and several publications indicated that when applied together with vitamins and minerals, they could give greater benefits than each of these treatments alone. Therefore, supplementation with vitamins, minerals, and pro/pre/synbiotics in obesity treatment plans may be recommended; however, further research is required to mitigate risks and optimize the effects achieved.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-3417/14/11/4489Test; https://doaj.org/toc/2076-3417Test

الوصول الحر: https://doaj.org/article/c9c5d5be0ece415092d271ff29c24310Test

المؤلفون: Alicja Forma, Arkadiusz Grunwald, Patryk Zembala, Jacek Januszewski, Adam Brachet, Roksana Zembala, Kamila Świątek, Jacek Baj

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 9, p 4968 (2024)

مصطلحات موضوعية: micronutrients, breast cancer, vitamins, metallomics, nutritional status, nutrition, Biology (General), QH301-705.5, Chemistry, QD1-999

الوصف: Breast cancer is one of the most common cancers worldwide, at the same time being one of the most prevalent causes of women’s death. Many factors such as alcohol, weight fluctuations, or hormonal replacement therapy can potentially contribute to breast cancer development and progression. Another important factor in breast cancer onset includes micronutrient status. In this narrative review, we analyzed 23 micronutrients and their possible influence on breast cancer onset and progression. Further, the aim of this study was to investigate the impact of micronutrient status on the prevention of breast cancer and its possible influence on various therapeutic pathways. We researched meta-analyses, systemic and narrative reviews, retrospective studies, as well as original studies on human and animal models. The results of these studies indicate a possible correlation between the different levels of micronutrients and a decreased risk of breast cancer as well as a better survival rate. However, further studies are necessary to establish adequate doses of supplementation of the chosen micronutrients and the exact mechanisms of micronutrient impact on breast cancer therapy.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/25/9/4968Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/c1e45414a708448c989a71f108e6af48Test

المؤلفون: Magdalena Tyczyńska, Gabriela Hunek, Martyna Szczasny, Adam Brachet, Jacek Januszewski, Alicja Forma, Piero Portincasa, Jolanta Flieger, Jacek Baj

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 9, p 4916 (2024)

مصطلحات موضوعية: non-alcoholic fatty liver disease, micronutrients, macronutrients, nutrition, vitamins, unsaturated fats, Biology (General), QH301-705.5, Chemistry, QD1-999

الوصف: Non-alcoholic fatty liver disease (NAFLD) is a condition in which the pathological cumulation of fat with coexisting inflammation and damage of hepatic cells leads to progressive dysfunctions of the liver. Except for the commonly well-known major causes of NAFLD such as obesity, dyslipidemia, insulin resistance, or diabetes, an unbalanced diet and imbalanced nutritional status should also be taken into consideration. In this narrative review, we summarized the current knowledge regarding the micro- and macronutrient status of patients suffering from NAFLD considering various diets and supplementation of chosen supplements. We aimed to summarize the knowledge indicating which nutritional impairments may be associated with the onset and progression of NAFLD at the same time evaluating the potential therapy targets that could facilitate the healing process. Except for the above-mentioned objectives, one of the most important aspects of this review was to highlight the possible strategies for taking care of NAFLD patients taking into account the challenges and opportunities associated with the micronutrient status of the patients. The current research indicates that a supplementation of chosen vitamins (e.g., vitamin A, B complex, C, or D) as well as chosen elements such as zinc may alleviate the symptoms of NAFLD. However, there is still a lack of sufficient data regarding healthy ranges of dosages; thus, further research is of high importance in this matter.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/25/9/4916Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/308a3a1e3f0847bb85f50b3f154d7a09Test

المؤلفون: Rola A. Bekdash

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 7, p 4036 (2024)

مصطلحات موضوعية: brain, epigenetics, gene-environment interactions, mental health, metabolism, micronutrients, Biology (General), QH301-705.5, Chemistry, QD1-999

الوصف: The relationship between nutrition and brain health is intricate. Studies suggest that nutrients during early life impact not only human physiology but also mental health. Although the exact molecular mechanisms that depict this relationship remain unclear, there are indications that environmental factors such as eating, lifestyle habits, stress, and physical activity, influence our genes and modulate their function by epigenetic mechanisms to shape mental health outcomes. Epigenetic mechanisms act as crucial link between genes and environmental influences, proving that non-genetic factors could have enduring effects on the epigenome and influence health trajectories. We review studies that demonstrated an epigenetic mechanism of action of nutrition on mental health, focusing on the role of specific micronutrients during critical stages of brain development. The methyl-donor micronutrients of the one-carbon metabolism, such as choline, betaine, methionine, folic acid, VitB6 and VitB12 play critical roles in various physiological processes, including DNA and histone methylation. These micronutrients have been shown to alter gene function and susceptibility to diseases including mental health and metabolic disorders. Understanding how micronutrients influence metabolic genes in humans can lead to the implementation of early nutritional interventions to reduce the risk of developing metabolic and mental health disorders later in life.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/25/7/4036Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/407e64767bec409199f9eb604932ff19Test

المؤلفون: Pilar Blanco, Isaac Rodríguez, Victoria Fernández-Fernández, María Ramil, David Castrillo, Marta Acín-Albiac, Irene Adamo, Clara Fernández-Trujillo, Beatriz García-Jiménez, Alberto Acedo, Noemi Calvo-Portela, Andrea Parente-Sendín, Lara Acemel-Míguez, Flora Alonso-Vega

المصدر: Microorganisms, Vol 12, Iss 3, p 595 (2024)

مصطلحات موضوعية: bulk soil, vineyard, sustainable agriculture, micronutrients, pesticide residues, metagenomics, Biology (General), QH301-705.5

الوصف: Agricultural management influences the soil ecosystem by affecting its physicochemical properties, residues of pesticides and microbiome. As vineyards grow crops with the highest incidence of pesticides, the aim of this study was to evaluate the impact of conventional and sustainable management systems of vineyards from DOP Ribeiro on the soil’s condition. Samples from soils under three different management systems were collected, and the main soil physicochemical properties were evaluated. A selection of 50 pesticides were investigated by liquid chromatography with tandem mass spectrometry. The bacterial and fungal microbiomes were characterized through amplicon sequencing. The results show that organic agriculture positively influences soil pH and the concentration of some nutrients compared to conventional management. Our microbiome analysis demonstrated that transitioning from conventional to organic management significantly improves several BeCrop® indexes related to key microbial metabolism and soil bio-sustainability. Such a transition does not affect soil alpha diversity, but leads to a higher interconnected microbial network structure. Moreover, differential core genera and species for each management system are observed. In addition, the correlation of the microbiome with geographical distance is evidence of the existence of different microbial terroirs within DOP Ribeiro. Indeed, sustainable management leads to higher nutrient availability and enhances soil health in the short term, while lowering pesticide usage.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-2607/12/3/595Test; https://doaj.org/toc/2076-2607Test

الوصول الحر: https://doaj.org/article/38f6e04c053a49839b413872d6b04935Test