دورية أكاديمية
An observational study demonstrating the efficacy of interleukin-1 antagonist (anakinra) in critically-ill patients with hemophagocytic lymphohistiocytosis
| العنوان: | An observational study demonstrating the efficacy of interleukin-1 antagonist (anakinra) in critically-ill patients with hemophagocytic lymphohistiocytosis |
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| المؤلفون: | Henry K, Raschke RA |
| المصدر: | Southwest Journal of Pulmonary and Critical Care, Vol 18, Iss 6, Pp 177-186 (2019) |
| بيانات النشر: | Arizona Thoracic Society, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:General works LCC:Medical emergencies. Critical care. Intensive care. First aid |
| مصطلحات موضوعية: | H score, HLH, adult, anakinra, fungal infection, hemophagocytic lymphohistiocytosis, interleukin 1, multisystem organ failure, secondary, survival, General works, R5-130.5, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| الوصف: | Secondary hemophagocytic hymphohistiocytosis (HLH) is an underrecognized cause of multisystem organ failure (MSOF) in critically ill adults, associated with high mortality even when recommended etoposide-based treatments are administered. Anakinra, an interleukin-1 receptor antagonist, has shown promise in treating children with HLH. This retrospective case series describes seven adult patients who presented to our ICU with a unremitting syndrome consistent with sepsis / MSOF, who were subsequently diagnosed with secondary HLH and received anakinra. Five of seven (71%) survived. Two non-survivors died secondary to opportunistic fungal infections. Our study contributes to mounting observational evidence regarding anakinra’s possible efficacy in critically ill adults with HLH, and also raises awareness of possible infectious complications of its use. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2160-6773 |
| العلاقة: | http://www.swjpcc.com/critical-care/2019/6/28/an-observational-study-demonstrating-the-efficacy-of-interle.htmlTest; https://doaj.org/toc/2160-6773Test |
| DOI: | 10.13175/swjpcc034-19 |
| الوصول الحر: | https://doaj.org/article/8396e78077334e6fb0a3262ef946f15fTest |
| رقم الانضمام: | edsdoj.8396e78077334e6fb0a3262ef946f15f |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 21606773 |
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| DOI: | 10.13175/swjpcc034-19 |