دورية أكاديمية
Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood
| العنوان: | Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood |
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| المؤلفون: | Maja Baretić, Ivana Kraljević, Ivana Pavlić Renar |
| المصدر: | Acta Clinica Croatica, Vol 55., Iss 1., Pp 93-98 (2016) |
| بيانات النشر: | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Diabetes mellitus, type 1 – complications, Hypoglycemia prevention and control, Insulin – pump administration and dosage, Insulin infusion systems, Insulin pump, Adult, Medicine |
| الوصف: | The aim was to determine which adult type 1 diabetic patient receiving multiple daily injection therapy is the most appropriate candidate for insulin pump therapy, while taking into consideration limited insulin pump affordability in Croatia. A total of 145 type 1 diabetic patients (52% diagnosed in adult age) were monitored at the Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center from 2009 to 2014. Twenty-one patients started insulin pump therapy in adulthood (seven men and 14 women, median age 27). Five patients had chronic complications (retinopathy in two, polyneuropathy in one, and both nephropathy and retinopathy in two patients). The median HbA1c at the initiation of pump therapy was 6.95% versus 6.5% after 1 year of pump therapy. Patients were stratified according to indications for insulin pump therapy (frequent and/or severe hypoglycemia, specific lifestyle, having not reached glycemic goals despite adherence/labile diabetes, and preconception). Patients could meet more than one criterion. Initially, the occurrence of hypoglycemia was analyzed by 6-day continuous glucose monitoring, while re-evaluation was done after collecting history data at 1 year ± 3 months. Initially, all patients had a median of 5 hypoglycemias/6 days (30% nocturnal) versus 1 hypoglycemia/6 days (without nocturnal) after 1 year. The Wilcoxon signed-rank test yielded a statistically significant difference in hypoglycemic events, nocturnal hypoglycemia and HbA1c. Patients commencing insulin pump therapy due to hypoglycemia initially had median HbA1c of 6.7% with 7 hypoglycemia/6 days (50% nocturnal). After one year, median HbA1c was 6% with 1 hypoglycemia/6 days (without nocturnal). In conclusion, the main indication for insulin pump therapy in adults is the frequency of hypoglycemia, especially nocturnal ones. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0353-9466 1333-9451 |
| العلاقة: | https://hrcak.srce.hr/file/237763Test; https://doaj.org/toc/0353-9466Test; https://doaj.org/toc/1333-9451Test |
| DOI: | 10.20471/acc.2016.55.01.14 |
| الوصول الحر: | https://doaj.org/article/3657e5ca2a994117b06113019911b5e1Test |
| رقم الانضمام: | edsdoj.3657e5ca2a994117b06113019911b5e1 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 03539466 13339451 |
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| DOI: | 10.20471/acc.2016.55.01.14 |