دورية أكاديمية
Review of PIP2 in Cellular Signaling, Functions and Diseases
العنوان: | Review of PIP2 in Cellular Signaling, Functions and Diseases |
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المؤلفون: | Kalpana Mandal |
المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 21, p 8342 (2020) |
بيانات النشر: | MDPI AG, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | Phosphoinositides, PIP2, membrane dynamics, actin, intracellular trafficking, focal adhesion, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Phosphoinositides play a crucial role in regulating many cellular functions, such as actin dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion. Central to this process is phosphatidylinositol bisphosphate (PIP2). The levels of PIP2 in the membrane are rapidly altered by the activity of phosphoinositide-directed kinases and phosphatases, and it binds to dozens of different intracellular proteins. Despite the vast literature dedicated to understanding the regulation of PIP2 in cells over past 30 years, much remains to be learned about its cellular functions. In this review, we focus on past and recent exciting results on different molecular mechanisms that regulate cellular functions by binding of specific proteins to PIP2 or by stabilizing phosphoinositide pools in different cellular compartments. Moreover, this review summarizes recent findings that implicate dysregulation of PIP2 in many diseases |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
العلاقة: | https://www.mdpi.com/1422-0067/21/21/8342Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
DOI: | 10.3390/ijms21218342 |
الوصول الحر: | https://doaj.org/article/32a57afb744f4f56b316293194389f08Test |
رقم الانضمام: | edsdoj.32a57afb744f4f56b316293194389f08 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
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DOI: | 10.3390/ijms21218342 |