دورية أكاديمية
Effect of Selenium Micronutrient on Inflammatory Status in Autism Spectrum Disorder Children: A Randomized Control Trial
| العنوان: | Effect of Selenium Micronutrient on Inflammatory Status in Autism Spectrum Disorder Children: A Randomized Control Trial |
|---|---|
| المؤلفون: | Neny Triana, Mohammad Sulchan, Maria Mexitalia, Maria Suryani |
| المصدر: | Journal of Evidence-Based Care, Vol 13, Iss 1, Pp 44-51 (2023) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Nursing LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | autism spectrum disorder, inflammatory status, micronutrients, selenium, Nursing, RT1-120, Gynecology and obstetrics, RG1-991 |
| الوصف: | Background: Autism spectrum disorder (ASD) children are characterized by increased proinflammatory agents. Previous studies found that administration of selenium can reduce inflammation; however, those studies were conducted on ASD mice model, and no study was conducted on the ASD patients. It is suspected that selenium could improve the development of ASD children by decreasing inflammation.Aim: The present study aimed to evaluate the effect of selenium on inflammatory status in ASD children.Method: This study was a randomized control trial. A total of 66 ASD children were selected and were randomly allocated to the first selenium intervention group (n=22), second selenium intervention group (n=22), and group control (n=22). Selenium as functional food and supplement was given to the intervention group for three months. The inflammatory state was measured by IL-1β, IL-6, and TNF-α serum. The ASD severity was measured by the autism treatment evaluation checklist (ATEC). Moreover, the intention-to-treat analysis was used in this study. The Wilcoxon test was used to compare before and after the intervention and Kruskal-Wallis test to compare the changes after the intervention.Results: Based on findings of the present research, some insignificant changes in IL-1β, IL-6, and TNF-α were observed in the selenium intervention and control groups. The selenium intervention groups experienced a significant decrease in ATEC scores compared to the control group (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Persian |
| تدمد: | 2008-2487 2008-370X |
| العلاقة: | https://ebcj.mums.ac.ir/article_21954_e5cc0b0ad6045df3a63b7d4efa45549c.pdfTest; https://doaj.org/toc/2008-2487Test; https://doaj.org/toc/2008-370XTest |
| DOI: | 10.22038/ebcj.2023.67834.2775 |
| الوصول الحر: | https://doaj.org/article/ec26681cbb07420dae6930a04e0408c1Test |
| رقم الانضمام: | edsdoj.26681cbb07420dae6930a04e0408c1 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20082487 2008370X |
|---|---|
| DOI: | 10.22038/ebcj.2023.67834.2775 |