Purpose: To report a case of recurrent corneal ulcer caused by an oropharyngeal cavity pathogen. Observations: A patient presented with recurrent corneal ulcers with hypopyon. Leptotrichia species was eventually isolated from the corneal ulcer on bacterial polymerase chain reaction (PCR) after many negative bacterial culture attempts. Due to correct identification of the pathogen, it was discovered that the patient was exposing her eye to saliva. Modification of patient behavior and initiation of the appropriate antibacterial treatment resulted in resolution of recurrent episodes of active infection. Conclusions: Although Leptotrichia species are not typically ocular pathogens, they can become pathogenic in the cornea with direct transmission from the oral cavity to the eye.
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