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Review of PIP2 in Cellular Signaling, Functions and Diseases

التفاصيل البيبلوغرافية
العنوان: Review of PIP2 in Cellular Signaling, Functions and Diseases
المؤلفون: Kalpana Mandal
المصدر: International Journal of Molecular Sciences, Vol 21, Iss 21, p 8342 (2020)
بيانات النشر: MDPI AG, 2020.
سنة النشر: 2020
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: Phosphoinositides, PIP2, membrane dynamics, actin, intracellular trafficking, focal adhesion, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Phosphoinositides play a crucial role in regulating many cellular functions, such as actin dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion. Central to this process is phosphatidylinositol bisphosphate (PIP2). The levels of PIP2 in the membrane are rapidly altered by the activity of phosphoinositide-directed kinases and phosphatases, and it binds to dozens of different intracellular proteins. Despite the vast literature dedicated to understanding the regulation of PIP2 in cells over past 30 years, much remains to be learned about its cellular functions. In this review, we focus on past and recent exciting results on different molecular mechanisms that regulate cellular functions by binding of specific proteins to PIP2 or by stabilizing phosphoinositide pools in different cellular compartments. Moreover, this review summarizes recent findings that implicate dysregulation of PIP2 in many diseases
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
العلاقة: https://www.mdpi.com/1422-0067/21/21/8342Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test
DOI: 10.3390/ijms21218342
الوصول الحر: https://doaj.org/article/32a57afb744f4f56b316293194389f08Test
رقم الانضمام: edsdoj.32a57afb744f4f56b316293194389f08
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms21218342