دورية أكاديمية
Investigating the Mechanism of Arsenic-induced Ferroptosis in the Skin
| العنوان: | Investigating the Mechanism of Arsenic-induced Ferroptosis in the Skin |
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| المؤلفون: | Mehdi Koushki, Nasrin Amiri-Dashatan, Mitra Rezaei, Fatemeh Montazer, Abdolrahim Nikzamir, Reza Vafaee, Vahid Mansouri, Masoumeh Farahani |
| المصدر: | International Journal of Medical Toxicology and Forensic Medicine, Vol 13, Iss 4 (2023) |
| بيانات النشر: | Shaheed Beheshti University of Medical Sciences, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Toxicology. Poisons |
| مصطلحات موضوعية: | arsenic exposure, ferroptosis, mitochondria, cell death, skin, Medicine (General), R5-920, Toxicology. Poisons, RA1190-1270 |
| الوصف: | Background: Ferroptosis, an oxidative and iron-dependent cell death, is a new type of regulated cell death. There are few studies on the mechanisms of ferroptosis in the skin and related diseases. Arsenic is shown to induce ferroptosis cell death. This study aimed to decipher the relationship between arsenic exposure and ferroptosis cell death in the skin. Methods: Arsenic-gene interactions were obtained. Then, skin-specific arsenic-gene interactions were screened. Ferroptosis-related genes were identified. Analysis of functional and biological interactions was performed to identify possible mechanisms. Results: The arsenic-gene interactions and the ferroptosis-related genes showed an overlap of 59 genes. Functional enrichment, protein-protein interaction, and transcription factor (TF)/miRNA target gene interaction analyses were used to look into the mechanism of arsenic-induced ferroptosis in the skin. ACTB, CTNNB1, HSPA8, SRC, RACK1, CD44, and SQSTM1 were identified as key proteins. Gene ontology analysis of these proteins indicated the mitochondrial morphology and functionality changes following arsenic-induced ferroptosis in the skin. HIF1A and SP1 TFs regulate a large number of genes compared to other TFs. Ten miRNAs with high interaction with ferroptosis-associated genes were identified. Conclusion: This work investigated the mechanism of arsenic-induced ferroptosis in the skin and identified key genes and regulators, and functional analysis highlighted the role of mitochondria in this skin exposure. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2251-8762 2251-8770 |
| العلاقة: | https://journals.sbmu.ac.ir/ijmtfm/article/view/43485/32730Test; https://doaj.org/toc/2251-8762Test; https://doaj.org/toc/2251-8770Test |
| الوصول الحر: | https://doaj.org/article/9d561213af6148c08def599b5dd9e024Test |
| رقم الانضمام: | edsdoj.9d561213af6148c08def599b5dd9e024 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 22518762 22518770 |
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