دورية أكاديمية
Intervention time modified the effect of inulin on high‐fat diet‐induced obesity and gut microbial disorders
| العنوان: | Intervention time modified the effect of inulin on high‐fat diet‐induced obesity and gut microbial disorders |
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| المؤلفون: | Xiaofang Li, Ping Chen, Yingying Zhang, Jiaming Zhang, Shanshan Shen, Kaikai Li |
| المصدر: | Food Frontiers, Vol 4, Iss 2, Pp 933-944 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Food processing and manufacture |
| مصطلحات موضوعية: | chrono‐nutrition, circadian rhythm, gut microbiota, inulin, obesity, short chain fatty acids, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456 |
| الوصف: | Abstract Various epidemiological studies support that inulin improves the intestinal environment and decreases the risk of obesity. The same as host feeding rhythms, gut microbiota itself displays daily fluctuations in composition and function. The purpose of this study was to investigate the influences of intervention time of inulin to alleviate high‐fat diet (HFD)‐induced obesity based on chrono‐nutrition. Male C57BL/6J mice were given HFD and gavaged inulin at light‐on time (HFM) or light‐off time (HFN) daily. Energy expenditure (EE), 16S rRNA sequencing in colonic contents, and short‐chain fatty acids (SCFAs) analysis were carried out after 12 weeks. Both in HFM and HFN group, the HFD‐induced weight gain was significantly reduced by 20.91% and 23.32%, and the mice in HFN group showed no significant difference in weight gain with the control group. Besides, mice in HFN group showed a tendency to increase EE and fecal SCFAs contents in addition to the relative content of colonic beneficial bacteria. As the light‐off period of mice is their active period, these results suggested that inulin intake at active period exhibited relatively stronger effects on ameliorating obesity and improving the gut microbial environment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2643-8429 |
| العلاقة: | https://doaj.org/toc/2643-8429Test |
| DOI: | 10.1002/fft2.243 |
| الوصول الحر: | https://doaj.org/article/c668f705bae84561950761c2960e0483Test |
| رقم الانضمام: | edsdoj.668f705bae84561950761c2960e0483 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26438429 |
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| DOI: | 10.1002/fft2.243 |