دورية أكاديمية
HISTOPATHOLOGICAL STUDY OF DIFFERENT ORGANS OF CHARLES FOSTER RATS UNDER THE EXPOSURE OF PUERARIA TUBEROSA
| العنوان: | HISTOPATHOLOGICAL STUDY OF DIFFERENT ORGANS OF CHARLES FOSTER RATS UNDER THE EXPOSURE OF PUERARIA TUBEROSA |
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| المؤلفون: | Harsh Pandey, Shivani Srivastava, Mohan Kumar, Yamini BhusanTripathi |
| المصدر: | Exploratory Animal and Medical Research, Vol 11, Iss 1, Pp 100-109 (2021) |
| بيانات النشر: | West Bengal Veterinary Alumni Association, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Veterinary medicine |
| مصطلحات موضوعية: | histopathological alteration, oecd, organ toxicity, pueraria tuberosa, water extract, charles foster rats, Veterinary medicine, SF600-1100 |
| الوصف: | The present study was undertaken to investigate the safe doses of Pueraria tuberosa water extract (PTWE) on different organs. The OECD guidelines 407 of repeated toxicity was followed with respect to the selection of dose and days for different organs. The selected doses of PTWE were 250, 500, 1000 and 2000 mg/kg b wt for 7, 14, 21 and 28 days. Haematoxylin and eosin staining was used to study the morphological alterations in heart, intestine, testis, adrenal gland and spleen. In the present study, no adverse alterations in cardiac fibers of the heart, size and shapes in crypts and villi of intestine, seminiferous tubules and spermatozoa count in testis, three zones of adrenal gland, and spleen were seen in all treated groups of PTWE. There were no adverse morphological alterations found in described organs. The PTWE are safe at 1000 mg/kg b wt. up to 28 days and 2000 mg/ kg b. wt up to 21 days, respectively. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2277-470X 2319-247X |
| العلاقة: | http://www.animalmedicalresearch.org/Vol.11_Issue-1_June_2021/HISTOPATHOLOGICAL%20STUDY.pdfTest; https://doaj.org/toc/2277-470XTest; https://doaj.org/toc/2319-247XTest |
| DOI: | 10.52635/eamr/11.1.100-109 |
| الوصول الحر: | https://doaj.org/article/1235ff3c7bde4fb39a3e9c2794742db7Test |
| رقم الانضمام: | edsdoj.1235ff3c7bde4fb39a3e9c2794742db7 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 2277470X 2319247X |
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| DOI: | 10.52635/eamr/11.1.100-109 |