دورية أكاديمية
The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility
| العنوان: | The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility |
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| المؤلفون: | Jégu, Teddy, Veluchamy, Alaguraj, Ramirez-Prado, Juan S., Rizzi-Paillet, Charley, Perez, Magalie, Lhomme, Anaïs, Latrasse, David, Coleno, Emeline, Vicaire, Serge, Legras, Stéphanie, Jost, Bernard, Rougée, Martin, Barneche, Fredy, Bergounioux, Catherine, Crespi, Martin, Mahfouz, Magdy M., Hirt, Heribert, Raynaud, Cécile, Benhamed, Moussa |
| المصدر: | Jégu, T., A. Veluchamy, J. S. Ramirez-Prado, C. Rizzi-Paillet, M. Perez, A. Lhomme, D. Latrasse, et al. 2017. “The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility.” Genome Biology 18 (1): 114. doi:10.1186/s13059-017-1246-7. http://dx.doi.org/10.1186/s13059-017-1246-7Test. |
| بيانات النشر: | BioMed Central, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | HMS Scholarly Articles |
| مصطلحات موضوعية: | SWI/SNF, Chromatin, Morphogenesis, Phytochrome Interacting Factor, G-box, DNA accessibility, PIF4 |
| الوصف: | Background: Plant adaptive responses to changing environments involve complex molecular interplays between intrinsic and external signals. Whilst much is known on the signaling components mediating diurnal, light, and temperature controls on plant development, their influence on chromatin-based transcriptional controls remains poorly explored. Results: In this study we show that a SWI/SNF chromatin remodeler subunit, BAF60, represses seedling growth by modulating DNA accessibility of hypocotyl cell size regulatory genes. BAF60 binds nucleosome-free regions of multiple G box-containing genes, opposing in cis the promoting effect of the photomorphogenic and thermomorphogenic regulator Phytochrome Interacting Factor 4 (PIF4) on hypocotyl elongation. Furthermore, BAF60 expression level is regulated in response to light and daily rhythms. Conclusions: These results unveil a short path between a chromatin remodeler and a signaling component to fine-tune plant morphogenesis in response to environmental conditions. Electronic supplementary material The online version of this article (doi:10.1186/s13059-017-1246-7) contains supplementary material, which is available to authorized users. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471679/pdfTest/; Genome Biology |
| DOI: | 10.1186/s13059-017-1246-7 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490744Test |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAATest |
| رقم الانضمام: | edshld.1.33490744 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
| DOI: | 10.1186/s13059-017-1246-7 |
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