دورية أكاديمية
Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis
| العنوان: | Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis |
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| المؤلفون: | TCW, Julia, Carvalho, Claudia M.B., Yuan, Bo, Gu, Shen, Altheimer, Alyssa N., McCarthy, Shane, Malhotra, Dheeraj, Sebat, Jonathan, Siegel, Arthur J., Rudolph, Uwe, Lupski, James R., Levy, Deborah L., Brennand, Kristen J. |
| المصدر: | TCW, J., C. M. Carvalho, B. Yuan, S. Gu, A. N. Altheimer, S. McCarthy, D. Malhotra, et al. 2017. “Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis.” Stem Cell Reports 8 (3): 519-528. doi:10.1016/j.stemcr.2017.01.010. http://dx.doi.org/10.1016/j.stemcr.2017.01.010Test. |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | HMS Scholarly Articles |
| مصطلحات موضوعية: | 9p24.1, marker chromosome, human induced pluripotent stem cell, neural progenitor cell, schizophrenia, bipolar disorder, isogenic, mosaic |
| الوصف: | Summary In the process of generating presumably clonal human induced pluripotent stem cells (hiPSCs) from two carriers of a complex structural rearrangement, each having a psychotic disorder, we also serendipitously generated isogenic non-carrier control hiPSCs, finding that the rearrangement occurs as an extrachromosomal marker (mar) element. All confirmed carrier hiPSCs and differentiated neural progenitor cell lines were found to be mosaic. We caution that mar elements may be difficult to functionally evaluate in hiPSC cultures using currently available methods, as it is difficult to distinguish cells with and without mar elements in live mosaic cultures. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355568/pdfTest/; Stem Cell Reports |
| DOI: | 10.1016/j.stemcr.2017.01.010 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:32071982Test |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAATest |
| رقم الانضمام: | edshld.1.32071982 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
| DOI: | 10.1016/j.stemcr.2017.01.010 |
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