دورية أكاديمية
Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium
| العنوان: | Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium |
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| المؤلفون: | Norby, Faye L., Eryd, Samuel Adamsson, Niemeijer, Maartje N., Rose, Lynda M., Smith, Albert V., Yin, Xiaoyan, Agarwal, Sunil K., Arking, Dan E., Chasman, Daniel L., Chen, Lin Y., Eijgelsheim, Mark, Engström, Gunnar, Franco, Oscar H., Heeringa, Jan, Hindy, George, Hofman, Albert, Lutsey, Pamela L., Magnani, Jared W., McManus, David D., Orho-Melander, Marju, Pankow, James S., Rukh, Gull, Schulz, Christina-Alexandra, Uitterlinden, André G., Albert, Christine M., Benjamin, Emelia J., Gudnason, Vilmundur, Smith, J. Gustav, Stricker, Bruno H. C., Alonso, Alvaro |
| المصدر: | Norby, F. L., S. A. Eryd, M. N. Niemeijer, L. M. Rose, A. V. Smith, X. Yin, S. K. Agarwal, et al. 2016. “Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium.” PLoS ONE 11 (3): e0151932. doi:10.1371/journal.pone.0151932. http://dx.doi.org/10.1371/journal.pone.0151932Test. |
| بيانات النشر: | Public Library of Science, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | HMS Scholarly Articles |
| مصطلحات موضوعية: | Medicine and Health Sciences, Cardiology, Arrhythmia, Atrial Fibrillation, Biology and Life Sciences, Biochemistry, Lipids, Cholesterol, Molecular Biology, Macromolecular Structure Analysis, Lipid Analysis, Vascular Medicine, Blood Pressure, Proteins, Lipoproteins, Heart Failure, Coronary Heart Disease |
| الوصف: | Background: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts. Methods: We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of AF per 1-standard deviation (SD) increase of each lipid gene score. Results: During a mean follow-up of 12.0 years, 5434 (8.4%) incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI) were 1.01 (0.98–1.03); 0.98 (0.96–1.01); 0.98 (0.95–1.02); 0.99 (0.97–1.02), respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI) = 1.00 (0.97–1.03); 1.01 (0.99–1.04). Conclusions: In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801208/pdfTest/; PLoS ONE |
| DOI: | 10.1371/journal.pone.0151932 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318686Test |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAATest |
| رقم الانضمام: | edshld.1.26318686 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0151932 |