دورية أكاديمية
Improved adherence adjustment in the Coronary Drug Project
| العنوان: | Improved adherence adjustment in the Coronary Drug Project |
|---|---|
| المؤلفون: | Murray, Eleanor J., Hernán, Miguel A. |
| المصدر: | Murray, Eleanor J., and Miguel A. Hernán. 2018. “Improved adherence adjustment in the Coronary Drug Project.” Trials 19 (1): 158. doi:10.1186/s13063-018-2519-5. http://dx.doi.org/10.1186/s13063-018-2519-5Test. |
| بيانات النشر: | BioMed Central, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | HMS Scholarly Articles SPH Scholarly Articles |
| مصطلحات موضوعية: | Per-protocol effect, Intention-to-treat effect, Inverse-probability weighting, Coronary Drug Project, Adherence |
| الوصف: | Background: The survival difference between adherers and non-adherers to placebo in the Coronary Drug Project has been used to support the thesis that adherence adjustment in randomized trials is not generally possible and, therefore, that only intention-to-treat analyses should be trusted. We previously demonstrated that adherence adjustment can be validly conducted in the Coronary Drug Project using a simplistic approach. Here, we re-analyze the data using an approach that takes full advantage of recent methodological developments. Methods: We used inverse-probability weighted hazards models to estimate the 5-year survival and mortality risk when individuals in the placebo arm of the Coronary Drug Project adhere to at least 80% of the drug continuously or never during the 5-year follow-up period. Results: Adjustment for post-randomization covariates resulted in 5-year mortality risk difference estimates ranging from − 0.7 (95% confidence intervals (CI), − 12.2, 10.7) to 4.5 (95% CI, − 6.3, 15.3) percentage points. Conclusions: Our analysis confirms that appropriate adjustment for post-randomization predictors of adherence largely removes the association between adherence to placebo and mortality originally described in this trial. Trial registration ClinicalTrials.gov, Identifier: NCT00000482. Registered retrospectively on 27 October 1999. Electronic supplementary material The online version of this article (10.1186/s13063-018-2519-5) contains supplementary material, which is available to authorized users. |
| Original Identifier: | 0000-0003-0043-4901 |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836455/pdfTest/; Trials |
| DOI: | 10.1186/s13063-018-2519-5 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:35982127Test |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAATest |
| رقم الانضمام: | edshld.1.35982127 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
| DOI: | 10.1186/s13063-018-2519-5 |
|---|