دورية أكاديمية
In vitro models of cancer stem cells and clinical applications
| العنوان: | In vitro models of cancer stem cells and clinical applications |
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| المؤلفون: | S. Franco, Sara, Szczesna, Karolina, Iliou, Maria S., Al-Qahtani, Mohammed, Mobasheri, Ali, Kobolák, Julianna, Dinnyés, András |
| المصدر: | S. Franco, Sara, Karolina Szczesna, Maria S. Iliou, Mohammed Al-Qahtani, Ali Mobasheri, Julianna Kobolák, and András Dinnyés. 2016. “In vitro models of cancer stem cells and clinical applications.” BMC Cancer 16 (Suppl 2): 738. doi:10.1186/s12885-016-2774-3. http://dx.doi.org/10.1186/s12885-016-2774-3Test. |
| بيانات النشر: | BioMed Central, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | HMS Scholarly Articles |
| مصطلحات موضوعية: | Cancer stem cells, Cancer, In vitro models, Cancer therapy |
| الوصف: | Cancer cells, stem cells and cancer stem cells have for a long time played a significant role in the biomedical sciences. Though cancer therapy is more effective than it was a few years ago, the truth is that still none of the current non-surgical treatments can cure cancer effectively. The reason could be due to the subpopulation called “cancer stem cells” (CSCs), being defined as those cells within a tumour that have properties of stem cells: self-renewal and the ability for differentiation into multiple cell types that occur in tumours. The phenomenon of CSCs is based on their resistance to many of the current cancer therapies, which results in tumour relapse. Although further investigation regarding CSCs is still needed, there is already evidence that these cells may play an important role in the prognosis of cancer, progression and therapeutic strategy. Therefore, long-term patient survival may depend on the elimination of CSCs. Consequently, isolation of pure CSC populations or reprogramming of cancer cells into CSCs, from cancer cell lines or primary tumours, would be a useful tool to gain an in-depth knowledge about heterogeneity and plasticity of CSC phenotypes and therefore carcinogenesis. Herein, we will discuss current CSC models, methods used to characterize CSCs, candidate markers, characteristic signalling pathways and clinical applications of CSCs. Some examples of CSC-specific treatments that are currently in early clinical phases will also be presented in this review. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 1471-2407 |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073996/pdfTest/; BMC Cancer |
| DOI: | 10.1186/s12885-016-2774-3 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408168Test |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAATest |
| رقم الانضمام: | edshld.1.29408168 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
Full Text Finder | تدمد: | 14712407 |
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| DOI: | 10.1186/s12885-016-2774-3 |