دورية أكاديمية
Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer
| العنوان: | Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer |
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| المؤلفون: | Wu, Wenting, Wagner, Erin K., Hao, Yangyang, Rao, Xi, Dai, Hongji, Han, Jiali, Chen, Jinhui, Storniolo, Anna Maria V., Liu, Yunlong, He, Chunyan |
| المصدر: | Wu, Wenting, Erin K. Wagner, Yangyang Hao, Xi Rao, Hongji Dai, Jiali Han, Jinhui Chen, Anna Maria V. Storniolo, Yunlong Liu, and Chunyan He. 2016. “Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer.” Scientific Reports 6 (1): 32731. doi:10.1038/srep32731. http://dx.doi.org/10.1038/srep32731Test. |
| بيانات النشر: | Nature Publishing Group, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | HMS Scholarly Articles |
| الوصف: | Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, we analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. We revealed two distinctive co-expression patterns associated with breast cancer, reflecting different underlying regulatory mechanisms: (1) 516 pairs of lncRNA-mRNAs have differential co-expression pattern, in which the correlation between lncRNA and mRNA expression differs in tumor and normal breast tissue; (2) 291 pairs have dose-response co-expression pattern, in which the correlation is similar, but the expression level of lncRNA or mRNA differs in the two tissue types. We further validated our findings in TCGA dataset and annotated lncRNAs using TANRIC. One novel lncRNA, AC145110.1 on 8p12, was found differentially co-expressed with 127 mRNAs (including TOX4 and MAEL) in tumor and normal breast tissue and also highly correlated with breast cancer clinical outcomes. Functional enrichment and pathway analyses identified distinct biological functions for different patterns of co-expression regulations. Our data suggested that lncRNAs might be involved in breast tumorigenesis through the modulation of gene expression in multiple pathologic pathways. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011741/pdfTest/; Scientific Reports |
| DOI: | 10.1038/srep32731 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:29407754Test |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAATest |
| رقم الانضمام: | edshld.1.29407754 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/srep32731 |