دورية أكاديمية
Inflammatory and Repair Serum Biomarker Pattern. Association to Clinical Outcomes in COPD
| العنوان: | Inflammatory and Repair Serum Biomarker Pattern. Association to Clinical Outcomes in COPD |
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| المؤلفون: | Casanova, Ciro, Müllerova, Hana, de Torres, Juan P, Corado, Henneth, Varo, Nerea, Cordoba, Elizabeth, Zeineldine, Salah, Paz, Hildegarde, Baz, Rebeca, Cortopassi, Felipe, Pinto-Plata, Victor Manuel, Divo, Miguel Jose, Celli, Bartolome R |
| المصدر: | Pinto-Plata, Victor, Ciro Casanova, Hana Müllerova, Juan P. de Torres, Henneth Corado, Nerea Varo, Elizabeth Cordoba, et al. 2012. Inflammatory and repair serum biomarker pattern. Association to clinical outcomes in COPD. Respiratory Research 13:71. |
| بيانات النشر: | BioMed Central, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | HMS Scholarly Articles |
| مصطلحات موضوعية: | Exercise, Inflammation, Phenotypes, Repair, Survival |
| الوصف: | Background: The relationship between serum biomarkers and clinical expressions of COPD is limited. We planned to further describe this association using markers of inflammation and injury and repair. Methods: We studied lung function, comorbidities, exercise tolerance, BODE index, and quality of life in 253 COPD patients and recorded mortality over three years. Serum levels of Interleukins 6,8 and16, tumor necrosis factor alpha (TNF α) [inflammatory panel], vascular endothelial growth factor (VEGF), and matrix metalloproteinase 9 (MMP-9) [injury and repair panel] and pulmonary and activation-regulated chemokine (PARC/CCL-18) and monocyte chemotactic protein 1 (MCP-1/CCL2) [chemoattractant panel] were measured. We related the pattern of the biomarker levels to minimal clinically important differences (MCID) using a novel visualization method [ObServed Clinical Association Results (OSCAR) plot]. Results: Levels of the inflammatory markers IL-6, TNF α were higher and those of injury and repair lower (p < 0.01) with more advanced disease (GOLD 1 vs. 4). Using the OSCAR plot, we found that patients in the highest quartile of inflammatory and lowest quartile of injury and repair biomarkers level were more clinically compromised and had higher mortality (p < 0.05). Conclusions: In COPD, serum biomarkers of inflammation and repair are distinctly associated with important clinical parameters and survival. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 1465-9921 1465-993X |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493287/pdfTest/; Respiratory Research |
| DOI: | 10.1186/1465-9921-13-71 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10579213Test |
| رقم الانضمام: | edshld.1.10579213 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
Full Text Finder | تدمد: | 14659921 1465993X |
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| DOI: | 10.1186/1465-9921-13-71 |