دورية أكاديمية
Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study
| العنوان: | Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study |
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| المؤلفون: | Amdur, Richard L., Mukherjee, Monica, Go, Alan, Barrows, Ian R., Ramezani, Ali, Shoji, Jun, Reilly, Muredach P., Gnanaraj, Joseph, Deo, Raj, Roas, Sylvia, Keane, Martin, Master, Steve, Teal, Valerie, Soliman, Elsayed Z., Yang, Peter, Feldman, Harold, Kusek, John W., Tracy, Cynthia M., Raj, Dominic S. |
| المصدر: | Amdur, R. L., M. Mukherjee, A. Go, I. R. Barrows, A. Ramezani, J. Shoji, M. P. Reilly, et al. 2016. “Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study.” PLoS ONE 11 (2): e0148189. doi:10.1371/journal.pone.0148189. http://dx.doi.org/10.1371/journal.pone.0148189Test. |
| بيانات النشر: | Public Library of Science, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | HMS Scholarly Articles |
| مصطلحات موضوعية: | Medicine and Health Sciences, Cardiology, Arrhythmia, Atrial Fibrillation, Biology and Life Sciences, Immunology, Immune Response, Inflammation, Pathology and Laboratory Medicine, Signs and Symptoms, Nephrology, Chronic Kidney Disease, Biochemistry, Biomarkers, Bioassays and Physiological Analysis, Electrophysiological Techniques, Cardiac Electrophysiology, Electrocardiography, Physiology, Immune Physiology, Cytokines, Immune System, Innate Immune System, Developmental Biology, Molecular Development, Glycobiology, Glycoproteins, Fibrinogen, Anatomy, Body Fluids, Blood, Blood Plasma, Hematology |
| الوصف: | Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with chronic kidney disease (CKD). In this study, we examined the association between inflammation and AF in 3,762 adults with CKD, enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study. AF was determined at baseline by self-report and electrocardiogram (ECG). Plasma concentrations of interleukin(IL)-1, IL-1 Receptor antagonist, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor-β, high sensitivity C-Reactive protein, and fibrinogen, measured at baseline. At baseline, 642 subjects had history of AF, but only 44 had AF in ECG recording. During a mean follow-up of 3.7 years, 108 subjects developed new-onset AF. There was no significant association between inflammatory biomarkers and past history of AF. After adjustment for demographic characteristics, comorbid conditions, laboratory values, echocardiographic variables, and medication use, plasma IL-6 level was significantly associated with presence of AF at baseline (Odds ratio [OR], 1.61; 95% confidence interval [CI], 1.21 to 2.14; P = 0.001) and new-onset AF (OR, 1.25; 95% CI, 1.02 to 1.53; P = 0.03). To summarize, plasma IL-6 level is an independent and consistent predictor of AF in patients with CKD. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739587/pdfTest/; PLoS ONE |
| DOI: | 10.1371/journal.pone.0148189 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:25658348Test |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAATest |
| رقم الانضمام: | edshld.1.25658348 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0148189 |