دورية أكاديمية
Chronopharmacology of Anti-Convulsive Therapy
| العنوان: | Chronopharmacology of Anti-Convulsive Therapy |
|---|---|
| المؤلفون: | Ramgopal, Sriram, Thome-Souza, Sigride, Loddenkemper, Tobias |
| المصدر: | Ramgopal, Sriram, Sigride Thome-Souza, and Tobias Loddenkemper. 2013. Chronopharmacology of anti-convulsive therapy. Current Neurology and Neuroscience Reports 13(4): 339. |
| بيانات النشر: | Current Science Inc., 2013. |
| سنة النشر: | 2013 |
| المجموعة: | HMS Scholarly Articles |
| مصطلحات موضوعية: | Epilepsy, Chronotherapy, Chronopharmacology, Chronopharmacokinetics, Differential dosing, Seizures, Seizure patterns, Diurnal patterns, Closed loops, Melatonin, Light therapy, Dim light melatonin onset, DLMO, Circadian rhythms, Circadian pattern, Suprachiasmatic nucleus, Seizure tracking, Seizure diary, Chronopharmacodynamics, Pharmacokinetics, Pharmacodynamics |
| الوصف: | Approximately one-third of patients with epilepsy continue to have seizures despite antiepileptic therapy. Many seizures occur in diurnal, sleep/wake, circadian, or even monthly patterns. The relationship between biomarkers and state changes is still being investigated, but early results suggest that some of these patterns may be related to endogenous circadian patterns whereas others may be related to wakefulness and sleep or both. Chronotherapy, the application of treatment at times of greatest seizure susceptibility, is a technique that may optimize seizure control in selected patients. It may be used in the form of differential dosing, as preparations designed to deliver sustained or pulsatile drug delivery or in the form of ‘zeitgebers’ that shift endogenous rhythms. Early trials in epilepsy suggest that chronopharmacology may provide improved seizure control compared with conventional treatment in some patients. The present article reviews chronopharmacology in the treatment of epilepsy as well as future treatment avenues. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 1528-4042 1534-6293 |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607723/pdfTest/; Current Neurology and Neuroscience Reports |
| DOI: | 10.1007/s11910-013-0339-2 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10627603Test |
| رقم الانضمام: | edshld.1.10627603 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
| تدمد: | 15284042 15346293 |
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| DOI: | 10.1007/s11910-013-0339-2 |