دورية أكاديمية
Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells
| العنوان: | Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells |
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| المؤلفون: | Kim, Mi-Kyoung, Park, Hyun-Joo, Kim, Su-Ryun, Choi, Yoon Kyung, Bae, Soo-Kyung, Bae, Moon-Kyoung |
| المصدر: | Kim, Mi-Kyoung, Hyun-Joo Park, Su-Ryun Kim, Yoon Kyung Choi, Soo-Kyung Bae, and Moon-Kyoung Bae. 2015. “Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells.” The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology 19 (4): 327-334. doi:10.4196/kjpp.2015.19.4.327. http://dx.doi.org/10.4196/kjpp.2015.19.4.327Test. |
| بيانات النشر: | The Korean Physiological Society and The Korean Society of Pharmacology, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | HMS Scholarly Articles |
| مصطلحات موضوعية: | Orexin-A, Heme oxygenase-1, Angiogenesis, Vascular endothelial cells |
| الوصف: | The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the involvement of HO-1 in the angiogenic activity of orexin-A. We showed that orexin-A stimulates expression and activity of HO-1 in human umbilical vein endothelial cells (HUVECs). Furthermore, we showed that inhibition of HO-1 by tin (Sn) protoporphryin-IX (SnPP) reduced orexin-A-induced angiogenesis in vivo and ex vivo. Orexin-A-stimulated endothelial tube formation and chemotactic activity were also blocked in SnPP-treated vascular endothelial cells. Orexin-A treatment increased the expression of nuclear factor erythroid-derived 2 related factor 2 (Nrf2), and antioxidant response element (ARE) luciferase activity, leading to induction of HO-1. Collectively, these findings indicate that HO-1 plays a role as an important mediator of orexin-A-induced angiogenesis, and provide new possibilities for therapeutic approaches in pathophysiological conditions associated with angiogenesis. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 1226-4512 |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499644/pdfTest/; The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology |
| DOI: | 10.4196/kjpp.2015.19.4.327 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:17820926Test |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAATest |
| رقم الانضمام: | edshld.1.17820926 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
Full Text Finder | تدمد: | 12264512 |
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| DOI: | 10.4196/kjpp.2015.19.4.327 |