التفاصيل البيبلوغرافية
| العنوان: |
Swiss public health measures associated with reduced SARS-CoV-2 transmission using genome data. |
| المؤلفون: |
Nadeau, Sarah A., Vaughan, Timothy G., Beckmann, Christiane, Topolsky, Ivan, Chen, Chaoran, Hodcroft, Emma, Schär, Tobias, Nissen, Ina, Santacroce, Natascha, Burcklen, Elodie, Ferreira, Pedro, Jablonski, Kim Philipp, Posada-Céspedes, Susana, Capece, Vincenzo, Seidel, Sophie, Santamaria de Souza, Noemi, Martinez-Gomez, Julia M., Cheng, Phil, Bosshard, Philipp P., Levesque, Mitchell P. |
| المصدر: |
Science Translational Medicine; 1/25/2023, Vol. 15 Issue 680, p1-11, 11p |
| مصطلحات موضوعية: |
SARS-CoV-2, GENOMES, VIRAL transmission |
| مصطلحات جغرافية: |
SWITZERLAND |
| مستخلص: |
Genome sequences from evolving infectious pathogens allow quantification of case introductions and local transmission dynamics. We sequenced 11,357 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from Switzerland in 2020—the sixth largest effort globally. Using a representative subset of these data, we estimated viral introductions to Switzerland and their persistence over the course of 2020. We contrasted these estimates with simple null models representing the absence of certain public health measures. We show that Switzerland's border closures decoupled case introductions from incidence in neighboring countries. Under a simple model, we estimate an 86 to 98% reduction in introductions during Switzerland's strictest border closures. Furthermore, the Swiss 2020 partial lockdown roughly halved the time for sampled introductions to die out. Last, we quantified local transmission dynamics once introductions into Switzerland occurred using a phylodynamic model. We found that transmission slowed 35 to 63% upon outbreak detection in summer 2020 but not in fall. This finding may indicate successful contact tracing over summer before overburdening in fall. The study highlights the added value of genome sequencing data for understanding transmission dynamics. SARS-CoV-2 in Switzerland: SARS-CoV-2 in SwitzerlandPhylogenomics has been key to understanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dynamics. Nadeau et al. sequenced and analyzed thousands of SARS-CoV-2 genomes from 2020 Switzerland during the early stages of the pandemic. They inferred that SARS-CoV-2 was introduced into the country by multiple independent introductions that fueled subsequent local viral transmission. Strict border closures were strongly linked to a reduction in SARS-CoV-2 importation into Switzerland, highlighting the importance of both viral genome sequencing and public health measures.—CAC [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
