التفاصيل البيبلوغرافية
| العنوان: |
An optimal periconception maternal folate status for embryonic size: the Rotterdam Predict study. |
| المؤلفون: |
Uitert, EM, Ginkel, S, Willemsen, SP, Lindemans, J, Koning, AHJ, Eilers, PHC, Exalto, N, Laven, JSE, Steegers, EAP, Steegers‐Theunissen, RPM |
| المصدر: |
BJOG: An International Journal of Obstetrics & Gynaecology; Jun2014, Vol. 121 Issue 7, p821-829, 9p, 4 Charts, 1 Graph |
| مصطلحات موضوعية: |
FOLIC acid, FOLIC acid deficiency, FOLATE-binding proteins, MEMBRANE proteins, PREGNANCY, CONFIDENCE intervals |
| مستخلص: |
Objective To investigate the association between periconception maternal folate status and embryonic size. Design Prospective periconception cohort study. Setting Erasmus University Medical Centre, Rotterdam, the Netherlands. Population Seventy-seven singleton pregnancies recruited in 2009 and 2010. Methods We recruited women before 8 weeks of gestation and performed weekly three-dimensional ultrasound scans from enrolment up to 13 weeks of gestation. As a measure of embryonic growth, crown-rump length ( CRL) measurements were performed using V-Scope software in the BARCO I-Space. Maternal blood was collected to determine first-trimester long-term red blood cell ( RBC) folate status. Non-malformed live births were included in the analysis. We calculated quartiles of RBC folate, square root-transformed CRL data and performed multivariable linear mixed model analyses. Main outcome measures Serial first-trimester CRL measurements. Results In total, 484 ultrasound scans were performed in 77 women, in 440 (90.7%) of which CRLs could be measured. RBC folate in the third quartile (1513-1812 nmol/l) was significantly associated with an increased CRL compared with the first two quartiles (814-1512 nmol/l) and the upper quartile (1813-2936 nmol/l; Poverall = 0.03; adjusted for gestational age, smoking, body mass index and fetal sex). Compared with the third quartile, embryos in the upper quartile were 24.2% smaller at 6+0 weeks [4.1 mm (95% confidence interval 3.5, 4.7) versus 5.4 mm (95% confidence interval 4.8, 6.1)] and 7.6% smaller at 12+0 weeks [55.1 mm (95% confidence interval 52.9, 57.3) versus 59.6 mm (95% confidence interval 57.4, 62.0)] of gestation. Conclusions This study suggests that a very high maternal periconception folate status is associated with reduced embryonic size. Whether these effects are beneficial or harmful requires further investigation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
