التفاصيل البيبلوغرافية
| العنوان: |
Association of low skeletal muscle mass with the presence of advanced colorectal neoplasm: integrative analysis using three skeletal muscle mass indices. |
| المؤلفون: |
Lee, H. J., Lee, J. Y., Lee, M. J., Kim, H.‐K., Kim, N., Kim, G.‐U., Lee, J.‐S., Park, H. W., Chang, H.‐S., Yang, D.‐H., Choe, J., Byeon, J.‐S. |
| المصدر: |
Colorectal Disease; Oct2020, Vol. 22 Issue 10, p1293-1303, 11p |
| مصطلحات موضوعية: |
MUSCLE mass, SKELETAL muscle, BODY mass index, BIOELECTRIC impedance, TUMORS |
| مستخلص: |
Aim: This study aimed to evaluate an association between colorectal neoplasm (CRN) and skeletal muscle mass using three widely accepted skeletal muscle mass indices (SMIs) in a large population at average risk. Method: We performed a cross‐sectional study using a screening colonoscopy database of 33 958 asymptomatic subjects aged 40–75 years. Appendicular skeletal muscle mass (ASM) was measured using a bioelectrical impedance analyser. ASM adjusted for height squared (ASM/ht2), weight (ASM/wt) and body mass index (ASM/BMI) were used as indices for muscle mass. Logistic regression models were used to evaluate the association between SMIs and CRN. Results: In a multivariable‐adjusted model, the risk of an advanced CRN increased linearly with decreasing quartiles for all three SMIs. The adjusted odds ratios (ORs) for advanced CRN in quartiles 1, 2 and 3 of ASM/wt compared with that in quartile 4 were 1.279, 1.196 and 1.179, respectively (Ptrend = 0.017); for ASM/BMI, ORs were 1.307, 1.144 and 1.091, respectively (Ptrend = 0.002); and for ASM/ht2, ORs were 1.342, 1.169 and 1.062, respectively (Ptrend = 0.002). The risk of distally located advanced CRN was higher in quartile 1 than in quartile 4 for all three SMIs (ASM/wt, OR = 1.356; ASM/BMI, OR = 1.383; ASM/ht2, OR = 1.430). Conclusion: Our study demonstrated that low skeletal muscle mass was consistently associated with the presence of advanced CRN in a population at average risk regardless of the operational definition of the SMI, and it was particularly associated with distal advanced CRN. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
