المؤلفون: Holroyd S, Currie L, Wooten GF, Holroyd, S, Currie, L, Wooten, G F

المصدر: Journal of Neurology, Neurosurgery & Psychiatry; Jun2001, p734-738, 5p

مستخلص: Objective: This study was undertaken to determine the prevalence of hallucinations and delusions in Parkinson's disease, to describe such symptoms phenomenologically, and possibly to determine factors associated with their development. In addition, the role of the visual system in relation to visual hallucinations was examined.Method: 102 consecutive patients diagnosed with strictly defined Parkinson's disease were examined for the presence of hallucinations and delusions and assessed for visual acuity, cognition, depression using the geriatric depression scale, disease severity as measured by the UPDRS, and other clinical variables.Results: Of 102 consecutive patients, 29.4% (n=30) had hallucinations or delusions, four (3.9%) were determined to be psychotic due solely to delirium and were excluded from further analysis. Of the 98 remaining patients, 26.5% (n=26) had visual hallucinations. Among these, one patient also had delusions, two had auditory hallucinations, and one had gustatory hallucinations. Visual hallucinations were significantly associated with worse visual acuity, lower cognitive score, higher depression score, and worse disease severity. Hallucinations were not associated with history of psychiatric disease, dose or duration of levodopa or other antiparkinsonian medication treatment, or duration of illness.Conclusions: Visual hallucinations are common symptoms in Parkinson's disease and are most likely of multifactorial origin. Although higher doses of levodopa are known to be related clinically to hallucinations in individual patients, the results suggest that several underlying characteristics of patients with Parkinson's disease (disease severity, dementia, depression, worse visual acuity) may be more important determinants of which patients experience hallucinations. The data also provide preliminary evidence that abnormality of the visual system may be related to visual hallucinations in Parkinson's disease, as has been found in other disorders with visual hallucinations. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Neurology, Neurosurgery & Psychiatry is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Maritz J, Holroyd S, Maritz, Jonathan, Holroyd, Suzanne

المصدر: Journal of Psychiatric Practice®; May2006, Vol. 12 Issue 3, p195-199, 5p

المؤلفون: Bovell, D., Holroyd, S., Sultan, A., Latifi, S., Healy, M., Gray, J.

المصدر: Proceedings of the Physiological Society; 2019, Issue 43, p117P-118P, 2p

مصطلحات موضوعية: ACTIVE learning, SENSORY perception, MEDICAL students

المؤلفون: Cerdeño‐Tárraga, A. M., Efstratiou, A., Dover, L. G., Holden, M. T. G., Pallen, M., Bentley, S. D., Besra, G. S., Churcher, C., James, K. D., De Zoysa, A., Chillingworth, T., Cronin, A., Dowd, L., Feltwell, T., Hamlin, N., Holroyd, S., Jagels, K., Moule, S., Quail, M. A., Rabbinowitsch, E.

المصدر: Nucleic Acids Research; Nov2003, Vol. 31 Issue 22, p6516-6523, 8p

المؤلفون: Holroyd, S., Currie, L., Wooten, G. F.

المصدر: Journal of Neurology, Neurosurgery & Psychiatry; Jun2001, p734-738, 5p, 3 Charts

المؤلفون: Bowman, S., Lawson, D., Basham, D., Brown, D., Chillingworth, T., Churcher, C.M., Craig, A., Davies, R.M., Devlin, K., Feltwell, T., Gentles, S., Gwilliam, R., Hamlin, N., Harris, D., Holroyd, S., Hornsby, T., Horrocks, P., Jagels, K., Jassal, B., Kyes, S.

المصدر: Nature; 8/5/1999, Vol. 400 Issue 6744, p532, 7p, 3 Diagrams, 4 Charts, 2 Graphs

مصطلحات موضوعية: PLASMODIUM falciparum genetics, CHROMOSOMES, GENES, INTRONS, CHEMICAL structure

مستخلص: Reports the analysis of Plasmodium falciparum chromosome 3. Its comparison with chromosome 2; Novel features of chromosome organization and gene structure; Predictions regarding genes; Early release of sequence data.

المؤلفون: Geng, V., Eelen, P., Fillingham, S., Holroyd, S., Kiesbye, B., Pearce, I., Vahr, S.

المصدر: National Guideline Clearinghouse; 12/26/2011, p1-10, 10p

المؤلفون: Holroyd S, Durgee J

المصدر: Clinical Gerontologist; 1998, Vol. 18 Issue 3, p39-50, 12p

مستخلص: This study addresses the effectiveness and tolerability of venlafaxine in geriatric psychiatry outpatients with treatment refractory major depression. All patients from a geriatric psychiatry outpatient clinic with major depression who had received at least one prescription for venlafaxine during a 12 month period were examined for treatment refractory criteria. Ten patients receiving venlafaxine met strictly defined criteria for treatment refractory depression. Of these, 8 (80%) had a complete response to venlafaxine, including two patients who had previously only been stabilized by maintenance ECT (mECT). Two patients required another concurrent psychiatric medication to achieve full response (lithium and methylphenidate augmentation). Venlafaxine was generally well tolerated, with 2 (20%) patients discontinuing its use due to side effects. Of 8 patients with a past history of side effects on other antidepressants, 6 (75%) had no reported side effects with venlafaxine. However, two patients (both responders) had severe apparent withdrawal/discontinuation symptoms upon sudden cessation of venlafaxine. Of the responders, seven (88%) currently remain in remission (mean time well of 24 months), and one (12%) relapsed at 14 months. Venlafaxine thus appears to be a promising antidepressant among geriatric patients with treatment refractory depression; however, clinicians should be aware of the possibility of a severe withdrawal/discontinuation syndrome and caution patients not to suddenly discontinue venlafaxine. [ABSTRACT FROM AUTHOR]

: Copyright of Clinical Gerontologist is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Clayton AH, Holroyd S, Sheldon-Keller A

المصدر: Clinical Gerontologist; 1997, Vol. 17 Issue 3, p3-13, 11p

مستخلص: We administered the Hamilton Rating Scale for Depression (HAM-D) and the Geriatric Depression Scale (GDS) to twenty-two elderly, cognitively intact subjects who met DSM-III-R criteria for Generalized Anxiety Disorder. The sample comprised 14 males and 8 females, with a mean age of 66.05 years. The two scales had a low intercorrelation (Pearson's r = .33). The GDS in our sample appeared much more sensitive in eliciting depressive symptoms than the HAM-D. Frequently reported symptoms of depression in this elderly sample were well represented on the Geriatric Depression Scale. For example, most of the patients reported diminished social activities with accompanying malaise and boredom. Cognitive and affective symptoms were also widely reported. In contrast, these symptoms are not assessed as thoroughly on the HAM-D, with few items addressing these symptoms. [ABSTRACT FROM AUTHOR]

: Copyright of Clinical Gerontologist is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: HOLROYD, SUZANNE, RABINS, PETER V., FINKELSTEIN, DANIEL, LAVRISHA, MARTINA, Holroyd, S, Rabins, P V, Finkelstein, D, Lavrisha, M

المصدر: Journal of Nervous & Mental Disease; May1994, Vol. 182 Issue 5, p273-276, 4p