المؤلفون: Xu, Bin, Chen, Jie‐Fu, Sarungbam, Judy, Tickoo, Satish, Dickson, Brendan C., Reuter, Victor E., Antonescu, Cristina R.

المصدر: Genes, Chromosomes & Cancer; Sep2022, Vol. 61 Issue 9, p542-550, 9p

المؤلفون: Alghamdi, Mohammed, Chen, Jie-Fu, Jungbluth, Achim, Koutzaki, Sirma, Palmer, Matthew B., Al-Ahmadie, Hikmat A., Fine, Samson W., Gopalan, Anuradha, Sarungbam, Judy, Sirintrapun, S. Joseph, Tickoo, Satish K., Reuter, Victor E., Chen, Ying-Bei

المصدر: Modern Pathology; May2024, Vol. 37 Issue 5, pN.PAG-N.PAG, 1p

المؤلفون: Cavassani, Karen A., Meza, Rebecca J., Habiel, David M., Chen, Jie‐Fu, Montes, Alexander, Tripathi, Manisha, Martins, Gislâine A., Crother, Timothy R., You, Sungyong, Hogaboam, Cory M., Bhowmick, Neil, Posadas, Edwin M.

المصدر: Cancer Medicine; Sep2018, Vol. 7 Issue 9, p4639-4649, 11p

مصطلحات موضوعية: PROSTATE cancer, CANCER immunology, MYELOID leukemia, MONOCYTES, EPITHELIAL cells, CANCER cell motility, DISEASE progression

مستخلص: Abstract: Background: Recruited myeloid cells are known to promote cancer initiation, malignant progression, metastasis, and resistance to therapy in the tumor niche. We tested the hypothesis that circulating blood monocytes from advanced prostate cancer (PCa) patients exhibit a protumor phenotype and directly influence the tumor microenvironment in response to tumor‐derived signals. Methods: Blood monocytes from advanced and stable PCa patients were cultured, and the conditioned media (CM) were collected and analyzed using standard invasion and wound closure assays to measure effects on invasion and motility of PCa tumor cells. We then identified the proteome profile of these monocytes using proteome array and ELISA. Results: Conditioned media from circulating monocytes in patients with metastatic prostate cancer (PCa‐M) increased invasion of epithelial PCa cells in vitro. Proteome Profiler Analysis revealed that monocyte‐derived CM from metastatic castration‐resistant (mCRPC) patients presented high levels of chitinase‐3‐like 1 (CHI3L1, YKL‐40) when compared to patients with stable disease (PCa‐N) and healthy control individuals (HC). The only described receptor for CHI3L1, interleukin‐13 receptor α2 (IL‐13Rα2), was significantly up‐regulated in the human metastatic PCa cell line, ARCaPM. Accordingly, we observed that the activation of IL‐13Rα2 from PCa‐M CM increased the invasiveness of ARCaPM cells while siRNA directed against this receptor significantly reduced invasiveness of these cells in the presence of CM from PCa‐M patients. Conclusions: Thus, we show that circulating monocytes from metastatic PCa patients exert a tumor‐promoting role via the secretion of CHI3L1, and CHI3L1 demands further exploration as a possible therapeutic target in advanced PCa. [ABSTRACT FROM AUTHOR]

: Copyright of Cancer Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Shen, Mo‐Yuan, Chen, Jie‐Fu, Luo, Chun‐Hao, Lee, Sangjun, Li, Cheng‐Hsuan, Yang, Yung‐Ling, Tsai, Yu‐Han, Ho, Bo‐Cheng, Bao, Li‐Rong, Lee, Tien‐Jung, Jan, Yu Jen, Zhu, Ya‐Zhen, Cheng, Shirley, Feng, Felix Y., Chen, Peilin, Hou, Shuang, Agopian, Vatche, Hsiao, Yu‐Sheng, Tseng, Hsian‐Rong, Posadas, Edwin M.

المصدر: Advanced Healthcare Materials; Feb2018, Vol. 7 Issue 3, p1-1, 9p

المؤلفون: Chen, Jie‐Fu, Ho, Hao, Lichterman, Jake, Lu, Yi‐Tsung, Zhang, Yang, Garcia, Mitch A., Chen, Shang‐Fu, Liang, An‐Jou, Hodara, Elisabeth, Zhau, Haiyen E., Hou, Shuang, Ahmed, Rafi S., Luthringer, Daniel J., Huang, Jiaoti, Li, Ker‐Chau, Chung, Leland W. K., Ke, Zunfu, Tseng, Hsian‐Rong, Posadas, Edwin M.

المصدر: Cancer (0008543X); Sep2015, Vol. 121 Issue 18, p3240-3251, 12p

مصطلحات موضوعية: PROSTATE cancer, TUMOR classification, CELL migration, CELL nuclei, METASTASIS, GAUSSIAN mixture models, PATIENTS

مستخلص: BACKGROUND Although enumeration of circulating tumor cells (CTCs) has shown some clinical value, the pool of CTCs contains a mixture of cells that contains additional information that can be extracted. The authors subclassified CTCs by shape features focusing on nuclear size and related this with clinical information. METHODS A total of 148 blood samples were obtained from 57 patients with prostate cancer across the spectrum of metastatic states: no metastasis, nonvisceral metastasis, and visceral metastasis. CTCs captured and enumerated on NanoVelcro Chips (CytoLumina, Los Angeles, Calif) were subjected to pathologic review including nuclear size. The distribution of nuclear size was analyzed using a Gaussian mixture model. Correlations were made between CTC subpopulations and metastatic status. RESULTS Statistical modeling of nuclear size distribution revealed 3 distinct subpopulations: large nuclear CTCs, small nuclear CTCs, and very small nuclear CTCs (vsnCTCs). Small nuclear CTCs and vsnCTC identified those patients with metastatic disease. However, vsnCTC counts alone were found to be elevated in patients with visceral metastases when compared with those without (0.36 ± 0.69 vs 1.95 ± 3.77 cells/mL blood; P<.001). Serial enumeration studies suggested the emergence of vsnCTCs occurred before the detection of visceral metastases. CONCLUSIONS There are morphologic subsets of CTCs that can be identified by fundamental pathologic approaches, such as nuclear size measurement. The results of this observational study strongly suggest that CTCs contain relevant information regarding disease status. In particular, the detection of vsnCTCs was found to be correlated with the presence of visceral metastases and should be formally explored as a putative blood-borne biomarker to identify patients at risk of developing this clinical evolution of prostate cancer. Cancer 2015;121:3240-3251. © 2015 American Cancer Society. [ABSTRACT FROM AUTHOR]

: Copyright of Cancer (0008543X) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Hou, Shuang, Choi, Jin‐sil, Chen, Kuan‐Ju, Zhang, Yang, Peng, Jinliang, Garcia, Mitch A., Yu, Jue‐Hua, Thakore‐Shah, Kaushali, Ro, Tracy, Chen, Jie‐Fu, Peyda, Parham, Fan, Guoping, Pyle, April D., Wang, Hao, Tseng, Hsian‐Rong

المصدر: Small; Jun2015, Vol. 11 Issue 21, p2499-2504, 6p

المؤلفون: Dong, Jiantong, Chen, Jie‐Fu, Smalley, Matthew, Zhao, Meiping, Ke, Zunfu, Zhu, Yazhen, Tseng, Hsian‐Rong

المصدر: Advanced Materials; 1/9/2020, Vol. 32 Issue 1, pN.PAG-N.PAG, 1p

المؤلفون: Dong, Jiantong, Chen, Jie‐Fu, Smalley, Matthew, Zhao, Meiping, Ke, Zunfu, Zhu, Yazhen, Tseng, Hsian‐Rong

المصدر: Advanced Materials; 1/9/2020, Vol. 32 Issue 1, pN.PAG-N.PAG, 1p

المؤلفون: Shen, Mo‐Yuan, Chen, Jie‐Fu, Luo, Chun‐Hao, Lee, Sangjun, Li, Cheng‐Hsuan, Yang, Yung‐Ling, Tsai, Yu‐Han, Ho, Bo‐Cheng, Bao, Li‐Rong, Lee, Tien‐Jung, Jan, Yu Jen, Zhu, Ya‐Zhen, Cheng, Shirley, Feng, Felix Y., Chen, Peilin, Hou, Shuang, Agopian, Vatche, Hsiao, Yu‐Sheng, Tseng, Hsian‐Rong, Posadas, Edwin M.

المصدر: Advanced Healthcare Materials; Feb2018, Vol. 7 Issue 3, p1-1, 1p

المؤلفون: Chen, Jie-Fu, Ho, Hao, Hodara, Elisabeth, Ureno, Alexandar, Go, Ann, Kaufman, Elizabeth, Sievert, Margarit, Luthringer, Daniel, Huang, Jiaoti, Li, Ker-Chau, Ke, Zunfu, Chung, Leland, Tseng, Hsian-Rong, Posadas, Edwin

المصدر: Journal of Urology; Apr2016 Supplement, Vol. 195, pe78-e78, 1p