التفاصيل البيبلوغرافية
| العنوان: |
Lipoprotein (a) levels in diabetes mellitus: relationship to metabolic control. |
| المؤلفون: |
Ramirez, Luis C., Arauz-Pacheco, Carlos, Lackner, Carolin, Albright, George, Adams, Beverly V., Raskin, Philip, Ramirez, L C, Arauz-Pacheco, C, Lackner, C, Albright, G, Adams, B V, Raskin, P |
| المصدر: |
Annals of Internal Medicine; 7/1/92, Vol. 117 Issue 1, p42-47, 6p, 3 Charts |
| مصطلحات موضوعية: |
BLOOD lipoproteins, DIABETES, SERUM |
| مستخلص: |
Objective: To determine the influence of diabetes control on serum lipoprotein (a) concentrations.Setting: Diabetes clinic of a large metropolitan public hospital, with primary- and secondary-care patients.Design: A cross-sectional study. Comparisons of lipoprotein (a) concentrations were made between a normal control group, a group of diabetic patients with glycated hemoglobin (HbA1c) less than 8.0%, and a group of diabetic patients with HbA1c of 8.0% or higher.Patients: Ninety-five normal controls and 93 diabetic subjects (49 with insulin-dependent diabetes mellitus and 44 with noninsulin-dependent diabetes mellitus).Results: Sixty diabetic subjects with HbA1c levels of 8.0% or higher had higher (25 mg/dL) median levels of lipoprotein (a) when compared with either 93 normal controls (8.8 mg/dL) or 33 diabetic patients with HbA1c less than 8.0% (7.5 mg/dL) (P = 0.008 and P = 0.012, respectively). A similar pattern of distribution of lipoprotein (a) levels according to degree of metabolic control was seen in patients with insulin-dependent diabetes mellitus and noninsulin-dependent diabetes mellitus. No difference in the lipoprotein (a) distribution was noted between diabetic men and women. No correlation was observed between lipoprotein (a) levels and total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels.Conclusion: Lipoprotein (a) levels are elevated in poorly controlled diabetic patients. Increased levels of lipoprotein (a) may be a contributing factor to the high risk for atherosclerosis observed in diabetic patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
