التفاصيل البيبلوغرافية
| العنوان: |
类风湿关节炎患者肌骨超声半定量分级与疾病活动度及骨代谢平衡的关系 (Chinese) |
| المؤلفون: |
陈美西, 刘秉彦, 林坚平, 杨炳昂, 刘安, 廖卫 |
| المصدر: |
Shandong Medical Journal; 8/25/2017, Vol. 57 Issue 32, p62-64, 3p |
| Abstract (Chinese): |
目的探讨类风湿关节炎（RA)患者肌骨超声半定量分级与疾病活动度及骨代谢的关系。方法选取RA患者73例，根据28处关节疾病活动度评分进行分组，其中缓解期组11例、低活动期组23例、中活动期组26例、高活动期组14例。采用彩色多普勒超声诊断仪分别对患者7个手足关节的滑膜增生、血流信号、骨侵蚀和关节积液进行半定量评分；检测骨吸收血清标志物抗酒石酸酸性磷酸酶5b(TRACP5b)、I型胶原C端肽(CTX-I)，骨形成血清标志物骨保护素（OPG)、骨碱性磷酸酶（BALP)、I型前胶原羧基端前肽(PICP)、I型前胶原氨基端前肽(PINP);采用简单直线相关分析法分析肌骨超声半定量评分与骨吸收、骨形成血清标志物的相关性。结果缓解期组、低活动期组、中活动期组和高活动期组的滑膜增生、血流信号、骨侵蚀、关节积液评分及总分均呈逐渐上升趋势，血清TRACP5b、CTX-I水平呈逐渐上升趋势，血清OPG、BALP、PICP和PINP水平呈逐渐下降趋势，组间比较P均<0.05。肌骨超声定量评分与血清TRACP5b、CTX-I水平呈正相关性（R2分别为0.7061、0.6230，尸均<0.05)，与血清OPG、BALP、PICP和PINP水平呈负相关性（O分别为0.7547、0.7941、0.8274、0.6644，P均<0.05)。结论RA患者肌骨超声半定量分级与疾病活动度密切相关，并能反映骨代谢状态。 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
