التفاصيل البيبلوغرافية
| العنوان: |
Hypoglycaemia incidence and recovery during home use of hybrid closed‐loop insulin delivery in adults with type 1 diabetes. |
| المؤلفون: |
Ruan, Yue, Bally, Lia, Thabit, Hood, Leelarathna, Lalantha, Hartnell, Sara, Tauschmann, Martin, Wilinska, Malgorzata E., Evans, Mark L., Mader, Julia K., Kojzar, Harald, Dellweg, Sibylle, Benesch, Carsten, Arnolds, Sabine, Pieber, Thomas R., Hovorka, Roman |
| المصدر: |
Diabetes, Obesity & Metabolism; Aug2018, Vol. 20 Issue 8, p2004-2008, 5p |
| مصطلحات موضوعية: |
HYPOGLYCEMIA, CLOSED loop systems, INSULIN therapy, TYPE 1 diabetes, BLOOD sugar monitoring, GLYCEMIC control, DRUG delivery systems, PATIENTS |
| مستخلص: |
Glucose excursion was assessed prior to and post hypoglycaemia to increase understanding of hypoglycaemia incidence and recovery during hybrid closed‐loop insulin delivery. We retrospectively analysed data from 60 adults with type 1 diabetes who received, in a crossover randomized design, day‐and‐night hybrid closed‐loop insulin delivery and insulin pump therapy, the latter with or without real‐time continuous glucose monitoring. Over 4‐week study periods, we identified hypoglycaemic episodes, defined as sensor glucose <3.0 mmol/L, and analysed sensor glucose relative to the onset of hypoglycaemia. We identified 377 hypoglycaemic episodes during hybrid closed‐loop intervention vs 662 during control intervention (P < .001), with a predominant reduction of nocturnal hypoglycaemia. The slope of sensor glucose prior to hypoglycaemia was steeper during closed‐loop intervention than during control intervention (P < .01), while insulin delivery was reduced (P < .01). During both day and night, participants recovered from hypoglycaemia faster when treated by closed‐loop intervention. At 120 minutes post hypoglycaemia, sensor glucose levels were higher during closed‐loop intervention compared to the control period (P < .05). In conclusion, closed‐loop intervention reduces the risk of hypoglycaemia, particularly overnight, with swift recovery from hypoglycaemia leading to higher 2‐hour post‐hypoglycaemia glucose levels. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
